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Recently, the interest of psychedelics as pharmacological treatment for psychiatric disorders has increased significantly, including their use on problematic use of alcohol. This systematic review is aimed to analyse the last two decades of studies examining the relationship between classic psychedelics and alcohol consumption. We searched PubMed and PsycInfo for human and preclinical studies published between January 2000 to December 2021. The search identified 639 publications. After selection, 27 studies were included. Human studies (<jats:italic>n<\/jats:italic>\u2009=\u200920) generally show promising data and seem to indicate that classic psychedelics could help reduce alcohol consumption. Nevertheless, some of these studies present methodological concerns such as low number of participants, lack of control group or difficulty in determining the effect of classic psychedelics in isolation. On the other hand, preclinical studies (<jats:italic>n<\/jats:italic>\u2009=\u20097) investigating the effect of these compounds on voluntary alcohol consumption are scarce and show some conflicting data. Among these compounds, psilocybin seems to show the most consistent data indicating that this compound could be a potential candidate to treat alcohol use disorders. In the absence of understanding the biological and\/or psychological mechanisms, more studies including methodological quality parameters are needed to finally determine the effects of classic psychedelics on alcohol consumption.<\/jats:p>","DOI":"10.1111\/adb.13229","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T06:45:03Z","timestamp":1662014703000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Classic psychedelics and alcohol use disorders: A systematic review of human and animal studies"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0573-3863","authenticated-orcid":false,"given":"Javier","family":"Calleja\u2010Conde","sequence":"first","affiliation":[{"name":"Cardenal Cisneros Higher Education Center  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9008-0056","authenticated-orcid":false,"given":"Jose Angel","family":"Morales\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Faculty of Medicine Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor","family":"Echeverry\u2010Alzate","sequence":"additional","affiliation":[{"name":"School of Life and Nature Sciences Nebrija University  Madrid Spain"},{"name":"Department of Psychobiology and Methodology in Behavioral Sciences, Faculty of Psychology, Somosaguas Campus Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kora Mareen","family":"B\u00fchler","sequence":"additional","affiliation":[{"name":"Department of Psychobiology and Methodology in Behavioral Sciences, Faculty of Psychology, Somosaguas Campus Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Gin\u00e9","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Faculty of Medicine Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6668-6568","authenticated-orcid":false,"given":"Jose Antonio","family":"L\u00f3pez\u2010Moreno","sequence":"additional","affiliation":[{"name":"Department of Psychobiology and Methodology in Behavioral Sciences, Faculty of Psychology, Somosaguas Campus Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,31]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization (WHO).Global Status Report on Alcohol and Health 2018.2018. 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