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We here provide translational evidence from a daily clinical routine setting and investigated whether BMI and sex interact to predict 24\u2010month readmission risk in four naturalistic cohorts of a specialized addiction clinic (i.e., all patients admitted to the clinic from 2016 to 2020): (i) in\u2010patients (443 males and 197 females) and (ii) day clinic patients (241 males and 103 females) with a primary diagnosis of AUD; (iii) in\u2010patients (175 males and 98 females) and (iv) day clinic patients (174 males and 64 females) with a primary substance use disorder (SUD) other than alcohol. In the in\u2010patients with AUD, BMI interacted with sex to predict the 24\u2010month readmission risks (<jats:italic>p<\/jats:italic>\u00a0=\u20090.008; after adjustment for age and liver enzyme activities: <jats:italic>p<\/jats:italic>\u00a0=\u20090.012); with higher BMI, the risk increases significantly in males, whereas for females, the risk tends to decrease. In the group of overweight in\u2010patients, we found higher readmission rates in males relative to females with an odds ratio of 1.8 (<jats:italic>p<\/jats:italic>\u00a0=\u20090.038). No such significant effects were found in the other cohorts. This study's findings support previous results, suggesting that the easily accessible BMI may serve as a predictive and sex\u2010sensitive biomarker for outcome in in\u2010patients with AUD. Future studies are necessary to elucidate the underlying aetiopathological mechanisms.<\/jats:p>","DOI":"10.1111\/adb.13239","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T14:19:10Z","timestamp":1667398750000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Body mass index interacts with sex to predict readmission in in\u2010patients with alcohol use disorder"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9713-2939","authenticated-orcid":false,"given":"Sabine","family":"Hoffmann","sequence":"first","affiliation":[{"name":"Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health (CIMH), Medical Faculty Mannheim Heidelberg University  Mannheim Germany"},{"name":"Department of Biostatistics, Central Institute of Mental Health (CIMH), Medical Faculty Mannheim Heidelberg University  Mannheim 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Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5962-019X","authenticated-orcid":false,"given":"Patrick","family":"Bach","sequence":"additional","affiliation":[{"name":"Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health (CIMH), Medical Faculty Mannheim Heidelberg University  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang H.","family":"Sommer","sequence":"additional","affiliation":[{"name":"Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health (CIMH), Medical Faculty Mannheim Heidelberg University  Mannheim Germany"},{"name":"Department of Psychopharmacology, Central Institute of Mental Health (CIMH), Medical Faculty Mannheim Heidelberg University  Mannheim Germany"},{"name":"Bethanian Hospital for Psychiatry, Psychosomatics and Psychotherapy  Greifswald 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