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There are several challenges with modelling oxycodone abuse. First, prescription opioids including oxycodone are orally self\u2010administered and have different pharmacokinetics and dynamics than morphine or fentanyl, which have been more commonly used in rodent research. This oral route of administration determines the pharmacokinetic profile, which then influences the establishment of drug\u2010reinforcement associations in animals. Moreover, the pattern of intake and the environment in which addictive drugs are self\u2010administered are critical determinants of the levels of drug intake, of behavioural sensitization and of propensity to relapse behaviour. These are all important considerations when modelling prescription opioid use, which is characterized by continuous drug access in familiar environments. Thus, to model features of prescription opioid use and the transition to abuse, we designed an oral, homecage\u2010based oxycodone self\u2010administration paradigm. 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