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However, there is lack of biomarkers to evaluate METH addiction in clinical practice, especially for gender differences. We utilized ultra\u2010high\u2010performance liquid chromatography\u2013tandem mass spectrometry (UHPLC\u2013MS\/MS) to detect the serum metabolomics in METH addicts and controls, specially exploring the sex\u2010specific metabolic alterations by METH abuse. We found that many differently expressed metabolites in METH addicts related to metabolisms of amino acid, energy, vitamin and neurological disorders. Further, METH abuse caused different patterns of metabolomics in a sex\u2010specific manner. As to amino acid metabolism, L\u2010phenylalanine, L\u2010tryptophan and L\u2010histidine in serum of male addicts and betaine in serum of female addicts were significantly changed by METH use. In addition, it seemed that purine and pyrimidine\u2010related metabolites (e.g., xanthosine and adenosine 5\u2032\u2010monophosphate) in male and the metabolites of hormone (e.g., cortisol) and folate biosynthesis (e.g., 7,8\u2010dihydrobiopterin and 4\u2010hydroxybenzoic acid) in female were more sensitive to METH addiction. Our findings revealed that L\u2010glutamic acid, L\u2010aspartic acid, alpha\u2010ketoglutarate acid and citric acid may be potential biomarkers for monitoring METH addiction in clinic. Considering sex\u2010specific toxicity by METH, the metabolites of purine and pyrimidine metabolism in male and those of stress\u2010related hormones in female may be used to facilitate the accurate diagnosis and treatment for METH addicts of different genders.<\/jats:p>","DOI":"10.1111\/adb.13255","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T12:33:19Z","timestamp":1669293199000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Sex\u2010specific metabolic signatures in methamphetamine addicts"],"prefix":"10.1111","volume":"28","author":[{"given":"Zhen","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Human Anatomy and Histoembryology Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqin","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy 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