{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T03:39:57Z","timestamp":1789184397649,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["100014_178841"],"award-info":[{"award-number":["100014_178841"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["32003B_166566"],"award-info":[{"award-number":["32003B_166566"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["BSSG10_155915"],"award-info":[{"award-number":["BSSG10_155915"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012545","name":"Foundation for Research in Science and the Humanities","doi-asserted-by":"publisher","award":["STWF\u201017\u2010012"],"award-info":[{"award-number":["STWF\u201017\u2010012"]}],"id":[{"id":"10.13039\/100012545","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007252","name":"Baugarten Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007252","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tobacco smoking is associated with deleterious health outcomes. Most smokers want to quit smoking, yet relapse rates are high. Understanding neural differences associated with tobacco use may help generate novel treatment options. Several animal studies have recently highlighted the central role of the thalamus in substance use disorders, but this research focus has been understudied in human smokers. Here, we investigated associations between structural and functional magnetic resonance imaging measures of the thalamus and its subnuclei to distinct smoking characteristics. We acquired anatomical scans of 32 smokers as well as functional resting\u2010state scans before and after a cue\u2010reactivity task. Thalamic functional connectivity was associated with craving and dependence severity, whereas the volume of the thalamus was associated with dependence severity only. Craving, which fluctuates rapidly, was best characterized by differences in brain function, whereas the rather persistent syndrome of dependence severity was associated with both brain structural differences and function. Our study supports the notion that functional versus structural measures tend to be associated with behavioural measures that evolve at faster versus slower temporal scales, respectively. It confirms the importance of the thalamus to understand mechanisms of addiction and highlights it as a potential target for brain\u2010based interventions to support smoking cessation, such as brain stimulation and neurofeedback.<\/jats:p>","DOI":"10.1111\/adb.13261","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T23:43:19Z","timestamp":1669851799000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Thalamic volume and functional connectivity are associated with nicotine dependence severity and craving"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7876-8632","authenticated-orcid":false,"given":"Cindy Sumaly","family":"Lor","sequence":"first","affiliation":[{"name":"Department of Cognition, Emotion, and Methods in Psychology University of Vienna  Vienna Austria"},{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics | Psychiatric University Hospital Zurich University of Zurich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9583-6585","authenticated-orcid":false,"given":"Amelie","family":"Haugg","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry and Psychotherapy | Psychiatric University Hospital Zurich University of Zurich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8655-5247","authenticated-orcid":false,"given":"Mengfan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cognition, Emotion, and Methods in Psychology University of Vienna  Vienna Austria"},{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics | Psychiatric University Hospital Zurich University of Zurich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5321-8711","authenticated-orcid":false,"given":"Letitia","family":"Schneider","sequence":"additional","affiliation":[{"name":"Division of Psychology and Language Sciences University College London  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5830-1971","authenticated-orcid":false,"given":"Marcus","family":"Herdener","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics | Psychiatric University Hospital Zurich University of Zurich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7933-2865","authenticated-orcid":false,"given":"Boris B.","family":"Quednow","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics | Psychiatric University Hospital Zurich University of Zurich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7388-4714","authenticated-orcid":false,"given":"Narly","family":"Golestani","sequence":"additional","affiliation":[{"name":"Brain and Language Lab | Cognitive Science Hub University of Vienna  Vienna Austria"},{"name":"Department of Behavioral and Cognitive Biology University of Vienna  Vienna Austria"},{"name":"Department of Psychology | Faculty of Psychology and Educational Sciences University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9973-2521","authenticated-orcid":false,"given":"Frank","family":"Scharnowski","sequence":"additional","affiliation":[{"name":"Department of Cognition, Emotion, and Methods in Psychology University of Vienna  Vienna Austria"},{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics | Psychiatric University Hospital Zurich University of Zurich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thorsurg.2013.01.009"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2013.03.008"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2009.06.011"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.8.907"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2017.0028"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnbeh.2021.720592","article-title":"Editorial: role of the thalamus in motivated behavior","volume":"15","author":"James MH","year":"2021","journal-title":"Front Behav Neurosci"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.05.018"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264\u2010018\u20100214\u2010x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnsys.2016.00104","article-title":"Cortico\u2010striatal\u2010thalamic loop circuits of the salience network: a central pathway in psychiatric disease and treatment","volume":"10","author":"Peters SK","year":"2016","journal-title":"Front Syst Neurosci"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-0775-0"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102451"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13011\u2010015\u20100011\u20108"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2014.06.018"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2019.09.005"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360\u20100443.1991.tb01879.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2005.05.017"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130000526"},{"issue":"2","key":"e_1_2_9_19_1","first-page":"115","article-title":"Fagerstrom test for nicotine dependence: reliability in a Turkish sample and factor analysis","volume":"52","author":"Uysal MA","year":"2004","journal-title":"Tuberk Toraks"},{"issue":"10","key":"e_1_2_9_20_1","first-page":"1130","article-title":"Reliability of the thai version of the Fagerstrom test for nicotine dependence (FTND)","volume":"100","author":"Klinsophon T","year":"2017","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2020.01.008"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.06.003"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201068008\u2010z"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.13083"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/14622200020032051"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000509758"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.08.012"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.04.042"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.018"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116189"},{"key":"e_1_2_9_31_1","first-page":"867","volume-title":"Human Brain Function","author":"Brett M","year":"2003"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2022.119340"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.10.011"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.138"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.120"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.08.003"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010006\u20100307\u20105"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.12"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2016.10.005"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20102952(95)02100\u20100"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.108.050716"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307\u2010019\u201001377\u20108"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006\u20103223(03)00610\u20103"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntx146"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP270492"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.140200"},{"key":"e_1_2_9_48_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnhum.2019.00065","article-title":"Real\u2010time fMRI neurofeedback in patients with tobacco use disorder during smoking cessation: functional differences and implications of the first training session in regard to future abstinence or relapse","volume":"13","author":"Karch S","year":"2019","journal-title":"Front Hum Neurosci"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.3791\/59441"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682\u2010017\u20109809\u20105"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.3109\/08990221003646736"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1223082"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.13261","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/adb.13261","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.13261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T21:51:03Z","timestamp":1692654663000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adb.13261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,30]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/adb.13261"],"URL":"https:\/\/doi.org\/10.1111\/adb.13261","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.09.25.509385","asserted-by":"object"}]},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,30]]},"assertion":[{"value":"2022-05-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13261"}}