{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:07:38Z","timestamp":1791234458329,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016238","name":"Alkoholitutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016238","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004212","name":"P\u00e4ivikki ja Sakari Sohlbergin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004212","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022793","name":"Turun Yliopistos\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003977","name":"National Center for Responsible Gaming","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008625","name":"GambleAware","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007553","name":"Gambling Research Exchange Ontario","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008723","name":"Suomen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Gambling disorder (GD) is major public health issue. The disorder is often characterized by elevated impulsivity with evidence from analogous substance use disorders underlining prominent roles of brain monoamines in addiction susceptibility and outcome. Critically, GD allows the study of addiction mechanisms without the confounder of the effects of chronic substances. Here, we assessed the roles of striatal dopamine transporter binding and extrastriatal serotonin transporter binding in GD as a function of impulsivity using [\n                    <jats:sup>123<\/jats:sup>\n                    I]FP\u2010CIT SPECT imaging in 20 older adults with GD (DSM\u20105 criteria; mean age 64\u2009years) and 40 non\u2010GD age\u2010 and sex\u2010matched controls. We focused on GD in older individuals because there are prominent age\u2010related changes in neurotransmitter function and because there are no reported neuroimaging studies of GD in older adults. Volume\u2010of\u2010interest\u2010based and voxelwise analyses were performed. GD patients scored clearly higher on impulsivity and had higher tracer binding in the ventromedial prefrontal cortex than controls (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), likely reflecting serotonin transporter activity. The binding in the medial prefrontal cortex positively correlated with impulsivity over the whole sample (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.62,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) as well as separately in GD patients (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.46,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04) and controls (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.52,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Striatal tracer binding, reflecting dopamine transporter activity was also positively correlated with impulsivity but showed no group differences. These findings highlight the role of prefrontal serotonergic function in GD and impulsivity. They identify cerebral coordinates of a potential target for neuromodulation for both GD and high impulsivity, a core phenotypic dimensional cognitive marker in addictions.\n                  <\/jats:p>","DOI":"10.1111\/adb.13264","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T21:05:42Z","timestamp":1673384742000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Serotonergic and dopaminergic control of impulsivity in gambling disorder"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3446-7093","authenticated-orcid":false,"given":"Valtteri","family":"Kaasinen","sequence":"first","affiliation":[{"name":"Clinical Neurosciences, Department of Clinical Medicine, Faculty of Medicine University of Turku  Turku Finland"},{"name":"Neurocenter Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma A.","family":"Honkanen","sequence":"additional","affiliation":[{"name":"Clinical Neurosciences, Department of Clinical Medicine, Faculty of Medicine University of Turku  Turku Finland"},{"name":"Neurocenter Turku University Hospital  Turku Finland"},{"name":"Turku PET Centre Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Lindholm","sequence":"additional","affiliation":[{"name":"Clinical Neurosciences, Department of Clinical Medicine, Faculty of Medicine University of Turku  Turku Finland"},{"name":"Neurocenter Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elina","family":"Jaakkola","sequence":"additional","affiliation":[{"name":"Clinical Neurosciences, Department of Clinical Medicine, Faculty of Medicine University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joonas","family":"Majuri","sequence":"additional","affiliation":[{"name":"Department of Neurology North Kymi Hospital  Kouvola Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riitta","family":"Parkkola","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Turku and Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommi","family":"Noponen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine University of Turku and Turku University Hospital  Turku Finland"},{"name":"Department of Medical Physics Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tero","family":"Vahlberg","sequence":"additional","affiliation":[{"name":"Biostatistics, Department of Clinical Medicine, Faculty of Medicine University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6790-1776","authenticated-orcid":false,"given":"Valerie","family":"Voon","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Cambridge  Cambridge UK"},{"name":"Institute of Science and Technology for Brain\u2010Inspired Intelligence Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Psychology and Djavad Mowafaghian Centre for Brain Health University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juho","family":"Joutsa","sequence":"additional","affiliation":[{"name":"Clinical Neurosciences, Department of Clinical Medicine, Faculty of Medicine University of Turku  Turku Finland"},{"name":"Neurocenter Turku University Hospital  Turku Finland"},{"name":"Turku PET Centre Turku University Hospital  Turku Finland"},{"name":"Turku Brain and Mind Center, Department of Clinical Medicine, Faculty of Medicine University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Sepp\u00e4nen","sequence":"additional","affiliation":[{"name":"Turku PET Centre Turku University Hospital  Turku Finland"},{"name":"Department of Clinical Physiology and Nuclear Medicine University of Turku and Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(17)32333\u20104"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2017.02.006"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2020.04.001"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2019.109852"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2013.03.004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2017.130"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.04.007"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.05.040"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.06.067"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.12066"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.02.006"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360\u20100443.2010.03126.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010018\u20100230\u20102"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2017.06.010"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.265"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12677"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2011.598559"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2017.09.007"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2020.09.034"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386\u2010019\u20100393\u20109"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2007.11.003"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13977"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(199711)27:3<183::AID-SYN4>3.0.CO;2-9"},{"issue":"7","key":"e_1_2_9_25_1","first-page":"1129","article-title":"SPECT imaging of dopamine transporters in human brain with iodine\u2010123\u2010fluoroalkyl analogs of beta\u2010CIT","volume":"37","author":"Abi\u2010Dargham A","year":"1996","journal-title":"J Nucl Med"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.111.102277"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301412"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073191113500522"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.01.016"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000000794"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369\u20101600.2011.00356.x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18\u201020\u201008417.1998"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2020.04.004"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010018\u20100260\u20109"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.12.024"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20344"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.10.050"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.24941"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2009.04.018"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.03.022"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.07.005"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2015_5013"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.07.025"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc7246"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.06.009"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.351"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12388"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.03.065"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12991\u2010017\u20100146\u20102"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2020.106657"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.05.020"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2019.02.013"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2012.07.011"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010018\u20100328\u2010y"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291710000486"},{"key":"e_1_2_9_56_1","unstructured":"van derMaasM NowerL MathesonFI TurnerNE MannRE.Sources of bias in research on gambling among older adults: considerations for a growing field."},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0912319107"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2013.36"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep01542"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2016.06.009"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2020.106813"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102013\u2010305395"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.00275"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.13264","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/adb.13264","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.13264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T13:01:21Z","timestamp":1692536481000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adb.13264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,10]]},"references-count":62,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1111\/adb.13264"],"URL":"https:\/\/doi.org\/10.1111\/adb.13264","archive":["Portico"],"relation":{},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,10]]},"assertion":[{"value":"2022-05-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13264"}}