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We conducted a population\u2010based case\u2013control and genetic association study in a large sample of young adults. Our aim was to assess the association between <jats:italic>DRD2<\/jats:italic> and <jats:italic>ANKK1<\/jats:italic> single nucleotide polymorphisms (SNPs) and harmful alcohol use, disentangling associated and possible intermediate factors. A total of 1841 college students from the French region Champagne\u2010Ardennes, aged between 18 and 21\u2009years and who reported at least one lifetime alcohol consumption, were included in this study. Allele frequencies were analysed according to harmful alcohol use (assessed through the Alcohol Use Disorder Identification Test [AUDIT] questionnaire). Different substance use disorders, including nicotine and cannabis dependences, were also assessed through questionnaires, as was a list of potential associated factors (e.g., major depressive episode, conduct disorder, attention\u2010deficit\/hyperactivity disorder [ADHD], school failure, sugar consumption, sexual trauma, parents' use of alcohol, tobacco or cannabis). We found that <jats:italic>DRD2<\/jats:italic> rs1800498 was associated with harmful alcohol use. Many factors were detected, but a global path analysis revealed that <jats:italic>DRD2<\/jats:italic> rs1800498 had a significant direct effect on harmful alcohol use and that early age at first alcohol consumption and depressive symptoms moderated this effect. This study suggests an interplay between harmful alcohol use, <jats:italic>DRD2<\/jats:italic> genotypes and other risk factors that, with a full understanding, could be useful for preventive purposes.<\/jats:p>","DOI":"10.1111\/adb.13269","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T07:31:42Z","timestamp":1675755102000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Associated and intermediate factors between genetic variants of the dopaminergic D2 receptor gene and harmful alcohol use in young adults"],"prefix":"10.1111","volume":"28","author":[{"given":"Julia","family":"Mattioni","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM, U1266 (Institute of Psychiatry and Neuroscience of Paris)  Paris France"},{"name":"CMME, GHU Paris Psychiatrie et Neurosciences, H\u00f4pital Sainte\u2010Anne  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e9ment","family":"Vansteene","sequence":"additional","affiliation":[{"name":"CMME, GHU Paris Psychiatrie et Neurosciences, H\u00f4pital Sainte\u2010Anne  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3712-0511","authenticated-orcid":false,"given":"Daphnee","family":"Poupon","sequence":"additional","affiliation":[{"name":"CMME, GHU Paris Psychiatrie et Neurosciences, H\u00f4pital Sainte\u2010Anne  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Gorwood","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM, U1266 (Institute of Psychiatry and Neuroscience of Paris)  Paris France"},{"name":"CMME, GHU Paris Psychiatrie et Neurosciences, H\u00f4pital Sainte\u2010Anne  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Ramoz","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM, U1266 (Institute of Psychiatry and Neuroscience of Paris)  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,6]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Global Status Report on Alcohol and Health","author":"World Health Organization","year":"2018"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2017.07.007"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.156.1.34"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e3283242f05"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439\u2010012\u20101164\u20104"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0920\u20109964(03)00220\u20102"},{"key":"e_1_2_9_8_1","unstructured":"NCBI.Home \u2010 SNP \u2010 NCBI.2021. 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