{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T14:40:35Z","timestamp":1788273635630,"version":"build-2803163510"},"reference-count":89,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA049886"],"award-info":[{"award-number":["DA049886"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014546","name":"New York State Psychiatric Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014546","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cocaine use is a public health concern in many countries worldwide, particularly in the Americas and Oceania. Overdose deaths involving stimulants, such as cocaine, have been increasing markedly in North America, especially with concurrent opioid involvement. To date, no pharmacological treatment is available to treat stimulant (including cocaine) use disorders. Prescription psychostimulants (PPs) could be useful to treat cocaine use disorder (CUD) as they share the pharmacological effects with cocaine, as evidenced by a recent meta\u2010analysis that assessed 38 randomized clinical trials (RCTs). PPs were found to promote sustained abstinence and reduce drug use in patients with CUD. The aim of this paper is to provide a narrative review of the clinical pharmacology of PPs and comment on the current stage of evidence supporting PPs to treat CUD. We also propose a model of care that integrates PPs with evidence\u2010based psychosocial interventions (such as cognitive\u2010behavioural therapy [CBT] and contingency management [CM]), a harm reduction approach and case management with social support.<\/jats:p>","DOI":"10.1111\/adb.13271","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T06:52:40Z","timestamp":1677653560000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prescription psychostimulants for cocaine use disorder: A review from molecular basis to clinical approach"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6040-7708","authenticated-orcid":false,"given":"Vitor S.","family":"Tardelli","sequence":"first","affiliation":[{"name":"Departamento de Psiquiatria Universidade Federal de Sao Paulo (Unifesp)  Sao Paulo SP Brazil"},{"name":"Translational Addiction Research Laboratory Center for Addiction and Mental Health  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4841-4117","authenticated-orcid":false,"given":"Lais F.","family":"Berro","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human Behavior University of Mississipi Medical Center  Jackson MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto","family":"Gerra","sequence":"additional","affiliation":[{"name":"Mental Health Department Azienda Unit\u00e1 Sanitaria Locale  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Tadonio","sequence":"additional","affiliation":[{"name":"Mental Health Department Azienda Unit\u00e1 Sanitaria Locale  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Bisaga","sequence":"additional","affiliation":[{"name":"The Department of Psychiatry, Vagelos College of Physicians and Surgeons Columbia University and the New York State Psychiatric Institute  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago M.","family":"Fidalgo","sequence":"additional","affiliation":[{"name":"Departamento de Psiquiatria Universidade Federal de Sao Paulo (Unifesp)  Sao Paulo SP Brazil"},{"name":"Young Leaders Program from the National Academy of Medicine  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Drug Report 2021(United Nations publication Sales No. E.21.XI.8)."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2014.02.005"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2013.10.019"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2021.2588"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12024\u2010020\u201000339\u20109"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.13897"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.14878"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606\u2010019\u201005074\u20108"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263\u2010020\u201000711\u2010x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2015.01.002"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000321465"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006306.pub3"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.13328"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.11.184"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010020\u201005563\u20103"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u201012\u2010385506\u20100.00001\u20106"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u201012\u2010420118\u20107.00004\u20104"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2007.08.003"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0014\u20102999(00)00639\u20107"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp900963n"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005\u20102728(93)90109\u2010s"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010017\u20104653\u20102"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010010\u20101839\u20102"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.1992.tb25966.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165\u20106147(92)90063\u2010c"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02740680"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.45"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20108993(93)90932\u2010d"},{"issue":"3","key":"e_1_2_10_30_1","first-page":"1678","article-title":"High affinity cocaine recognition sites on the dopamine transporter are elevated in fatal cocaine overdose victims","volume":"271","author":"Staley JK","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-08-02799.2001"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2604\u201017.2017"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386\u2010020\u20100773\u20101"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301420"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.04.007"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.7.1134"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0891\u20100618(00)00102\u20102"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091\u20103057(90)90232\u20107"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0376\u20108716(93)90067\u2010z"},{"issue":"3","key":"e_1_2_10_40_1","first-page":"1551","article-title":"Serotonergic modulation of the behavioral effects of cocaine in the squirrel monkey","volume":"275","author":"Howell LL","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050263"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.300.3.831"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386\u2010018\u20100071\u20103"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002209.pub2"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.12633"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.13158"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.14991"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2007.08.027"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beproc.2012.02.014"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2019.06.020"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2020.108219"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.140.6.784"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0740\u20105472(84)90033\u20103"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.3109\/00952998509016861"},{"key":"e_1_2_10_55_1","volume-title":"Methylphenidate: Adjunct in cocaine treatment","author":"Grabowski J","year":"1995"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714\u2010199712000\u201000008"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007380.pub4"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(16)00205\u20101"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2019.107700"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360\u20100443.2009.02717.x"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2010.307"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1080\/00952990.2021.1885677"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102020\u2010044696"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2015.1027903"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2018.10.002"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1037\/ccp0000552"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002715"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.8049"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12954\u2010019\u20100351\u20101"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0234809"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2015.04.021"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2016.06.007"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1037\/ccp0000126"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2015.09.005"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.12589"},{"key":"e_1_2_10_76_1","volume-title":"Treatment of stimulant use disorders: Current practices and promising perspectives","author":"United Nations Office on Drugs and Crime","year":"2019"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2019.03.031"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.3940"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2020.1511"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.7326\/M16\u20102149"},{"key":"e_1_2_10_81_1","volume-title":"Medication\u2010assisted treatment models of care for opioid use disorder in primary care settings","author":"Chou R","year":"2016"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100447.1990.tb03057.x"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1186\/1747\u2010597X\u20106\u20103"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.2021.1900627"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.3328"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.14030"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1080\/15504263.2017.1319586"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2016.10.001"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1186\/1747\u2010597X\u20102\u201010"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2015.11.004"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.13271","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/adb.13271","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.13271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T15:08:24Z","timestamp":1692630504000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adb.13271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":89,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/adb.13271"],"URL":"https:\/\/doi.org\/10.1111\/adb.13271","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.742605807.793598348","asserted-by":"object"}]},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"2022-05-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13271"}}