{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:10:44Z","timestamp":1793661044288,"version":"4.5.1"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T00:00:00Z","timestamp":1683244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["1R01 DA042490\u201001A1"],"award-info":[{"award-number":["1R01 DA042490\u201001A1"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cannabis legislation and attitudes towards use are changing. Given that evidence from cultural neuroscience research suggests that culture influences the neurobiological mechanisms underlying behaviour, it is of great importance to understand how cannabis legislation and attitudes might affect the brain processes underlying cannabis use disorder. Brain activity of 100 dependent cannabis users and 84 controls was recorded during an N\u2010back working memory (WM) task in participants from the Netherlands (NL; users\u2009=\u200960, controls\u2009=\u200952) and Texas, USA (TX; users\u2009=\u200940, controls\u2009=\u200932). Participants completed a cannabis culture questionnaire as a measure of perceived benefits (positive) and perceived harms (negative) of cannabis from their personal, friends\u2013family's and country\u2013state's perspectives. Amount of cannabis use (grams\/week), DSM\u20105 CUD symptoms and cannabis use\u2010related problems were assessed. Cannabis users self\u2010reported more positive and less negative (personal and friends\u2013family) cannabis attitudes than controls, with this effect being significantly larger in the TX cannabis users. No site difference in country\u2013state attitudes was observed. TX cannabis users, compared with NL cannabis users, and those cannabis users perceiving more positive country\u2013state attitudes showed a more positive association between grams\/week and WM\u2010related activity in the superior parietal lobe. NL cannabis users, compared with TX cannabis users, and those cannabis users with less positive personal attitudes showed a more positive association between grams\/week and WM\u2010load\u2010related activity in the temporal pole. Both site and cultural attitudes moderated the association of quantity of cannabis use with WM\u2010 and WM\u2010load\u2010related activity. Importantly, differences in legislation did not align with perceived cannabis attitudes and appear to be differentially associated with cannabis use\u2010related brain activity.<\/jats:p>","DOI":"10.1111\/adb.13283","type":"journal-article","created":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T01:28:34Z","timestamp":1683336514000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Working memory\u2010related brain activity in cannabis use disorder: The role of cross\u2010cultural differences in cannabis attitudes"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1803-9336","authenticated-orcid":false,"given":"Emese","family":"Kroon","sequence":"first","affiliation":[{"name":"ADAPT\u2010Laboratory, Department of Psychology University of Amsterdam  Amsterdam The Netherlands"},{"name":"Neuroscience of Addiction (NofA) Lab, Department of Psychology University of Amsterdam  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