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Alcohol, however, is rarely consumed in pure form but in fruit\u2010 or corn\u2010derived preparations, like beer. These preparations add other compounds to the consumption, which may critically modify alcohol intake and AUD risk. We investigated the effects of hordenine, a barley\u2010derived beer compound on alcohol use\u2010related behaviours. We found that the dopamine D2 receptor agonist hordenine (50\u2009mg\/kg) limited ongoing alcohol consumption and prophylactically diminished relapse drinking after withdrawal in mice. Although not having reinforcing effects on its own, hordenine blocked the establishment of alcohol\u2010induced conditioned place preference (CPP). However, it independently enhanced alcohol CPP retrieval. Hordenine had a dose\u2010dependent inhibitory effect on locomotor activity. Chronic hordenine exposure enhanced monoamine tissue levels in many brain regions. Further characterization revealed monoaminergic binding sites of hordenine and found a strong binding on the serotonin and dopamine transporters, and dopamine D<jats:sub>3<\/jats:sub>, and adrenergic \u03b1<jats:sub>1A<\/jats:sub> and \u03b1<jats:sub>2A<\/jats:sub> receptor activation but no effects on GABA<jats:sub>A<\/jats:sub> receptor or glycinergic signalling. These findings suggest that natural ingredients of beer, like hordenine, may work as an inhibitory and use\u2010regulating factor by their modulation of monoaminergic signalling in the brain.<\/jats:p>","DOI":"10.1111\/adb.13305","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T00:35:17Z","timestamp":1688517317000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The beer component hordenine inhibits alcohol addiction\u2010associated behaviours in mice"],"prefix":"10.1111","volume":"28","author":[{"given":"Yan","family":"Li","sequence":"first","affiliation":[{"name":"Food Chemistry, Department of Chemistry and Pharmacy Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Vogel","sequence":"additional","affiliation":[{"name":"Food Chemistry, 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