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The glutamatergic transmission from basolateral nucleus of amygdala (BLA) to the nucleus accumbens (NAc) modulates reward\u2010seeking behaviour; especially, NAc shell (NAsh) is implicated in reward\u2010seeking response. Previous studies indicated the interactions between AMPA receptors (AMPARs) and dopamine D1 receptor (D1R) in NAc mediated drug addiction, but whether the circuit of BLA\u2010to\u2010NAsh and AMPARs regulate propofol addiction remains unclear. We trained adult male Sprague\u2013Dawley rats for propofol self\u2010administration to examine the changes of action potentials (APs) and spontaneous excitatory postsynaptic currents (sEPSCs) in the NAsh. Thereafter, optogenetic stimulation with adeno\u2010associated viral vectors microinjections in BLA was used to explore the effect of BLA\u2010to\u2010NAsh on propofol self\u2010administration behaviour (1.7\u00a0mg\/kg\/injection). The pretreatment effects with NBQX (0.25\u20131.0\u00a0\u03bcg\/0.3\u00a0\u03bcl\/site) or vehicle in the NAsh on propofol self\u2010administration behaviour, the expressions of AMPARs subunits and D1R\/ERK\/CREB signalling pathway in the NAc were detected. The results showed that the number of APs, amplitude and frequency of sEPSCs were enhanced in propofol self\u2010administrated rats. Propofol self\u2010administration was inhibited in the NpHR3.0\u2010EYFP group, but in the ChR2\u2010EYFP group, there was a promoting effect, which could be weakened by NBQX pretreatment. NBQX pretreatment also significantly decreased the expressions of GluA2 subunit and D1R in the NAc but did not change the expressions of GluA1 and ERK\/CREB signalling pathway. The evidence supports a vital role of BLA\u2010to\u2010NAsh circuit in regulating propofol self\u2010administration and suggests this central reward processing may function through the interaction between AMPARs and D1R in the NAsh.<\/jats:p>","DOI":"10.1111\/adb.13310","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T00:04:35Z","timestamp":1688688275000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The excitatory transmission from basolateral nuclues of amygdala to nucleus accumbens shell regulates propofol self\u2010administration through AMPA receptors"],"prefix":"10.1111","volume":"28","author":[{"given":"Zhanglei","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Perioperative and Pain Medicine The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou China"},{"name":"Key Laboratory of 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Second Affiliated Hospital of Wenzhou Medical University  Wenzhou China"},{"name":"Key Laboratory of Pediatric Anesthesiology, Ministry of Education Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangning","family":"Shangguan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative and Pain Medicine The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou China"},{"name":"Key Laboratory of Anesthesiology of Zhejiang Province The Second Affiliated Hospital of Wenzhou Medical University  Wenzhou China"},{"name":"Key Laboratory of Pediatric Anesthesiology, Ministry of Education Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifeng","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative and Pain Medicine The Second Affiliated Hospital and 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