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Our previous studies have suggested that acupuncture at <jats:italic>Shenmen<\/jats:italic> (HT7) points modulates mesolimbic reward system in order to suppress drug\u2010induced addiction behaviours. To explore whether an mPFC\u2010LHb circuit mediates the inhibitory effects of acupuncture on addictive behaviours, we examined the projection from mPFC to LHb, excitation of mPFC neurons during acupuncture stimulation, the effects of optogenetic modulation of mPFC\u2010LHb on HT7 inhibition of cocaine\u2010induced locomotion and the effect of mPFC lesion on HT7 inhibition of nucleus accumbens (NAc) dopamine release. Acupuncture was applied at bilateral HT7 points for 20\u2009s, and locomotor activity was measured in male Sprague\u2013Dawley rats. Although cocaine injection significantly increased locomotor activity, HT7 acupuncture suppressed the cocaine\u2010induced locomotion. The inhibitory effect of HT7 on cocaine\u2010enhanced locomotion was blocked by optogenetic silencing of the mPFC\u2010LHb circuit. In vivo extracellular recordings showed that HT7 acupuncture evoked an increase in the action potentials of mPFC neurons. Optopatch experiment proved glutamatergic projections from mPFC to LHb. HT7 acupuncture suppressed NAc dopamine release following cocaine injection, which was blocked by electrolytic lesion of mPFC. These results suggest the mediation of mPFC\u2010LHb circuit in the inhibitory effects of acupuncture on cocaine psychomotor activity in rats.<\/jats:p>","DOI":"10.1111\/adb.13321","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T10:55:22Z","timestamp":1693997722000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mediation of mPFC\u2010LHb pathway in acupuncture inhibition of cocaine psychomotor activity"],"prefix":"10.1111","volume":"28","author":[{"given":"Suchan","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Physiology, College of Korean Medicine Daegu Haany University  Daegu South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung Kyu","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Korean Medicine Daegu Haany University  Daegu South Korea"},{"name":"Department of Oral 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