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The present study aimed to investigate the role of dynorphin\/\u03ba opioid receptor (KOR) system in the development of METH\u2010induced cognitive impairment. We found that mice showed significant cognitive impairment in the novel object recognition test (NOR) following daily injections of METH (10\u00a0mg\/kg) for seven consecutive days. Systemic blockade of KOR prevented METH\u2010induced cognitive impairment by pretreatment of the selective KOR antagonist norBNI (10\u00a0mg\/kg, i.p.) or KOR deletion. Then, significant increased dynorphin and KOR mRNA were observed exclusively in prelimbic cortex (PL) other than infralimbic cortex. Finally, microinjection with norBNI into PL also improved cognitive memory in METH\u2010treated mice using NOR and spontaneous alternation behaviour test. Our results demonstrated that dynorphin\/KOR system activation in PL may be a possible mechanism for METH\u2010induced cognitive impairment and shed light on KOR antagonists as a potential neuroprotective agent against the cognitive deficits induced by drug abuse.<\/jats:p>","DOI":"10.1111\/adb.13323","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T03:10:44Z","timestamp":1692760244000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Prelimbic cortex dynorphin\/\u03ba opioid receptor system modulates methamphetamine\u2010induced cognitive impairment"],"prefix":"10.1111","volume":"28","author":[{"given":"Ying\u2010jie","family":"Cheng","sequence":"first","affiliation":[{"name":"Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine  Shanghai 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