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However, the anatomical counterpart of these functional modifications in sAUD patients with and without neurological complications remains largely unexplored, especially using state\u2010of\u2010the\u2010art parcellation tools. We thus compared the grey matter volume of insular subregions (form anterior to posterior: anterior inferior cortex, anterior short gyrus, middle short gyrus, posterior short gyrus, anterior long gyrus, posterior long gyrus) in 50 recently detoxified patients with sAUD, 19 patients with Korsakoff's syndrome (KS) and 36 healthy controls (HC). We used a mixed linear model analysis to explore group differences in the six subregions grey matter volume and lateralization differences. Insular macrostructure was globally affected to the same extent in sAUD with and without KS, indicating that these brain abnormalities may be related to alcohol consumption per se, rather than to the presence of alcohol\u2010related neurological complications. Insular atrophy showed a right\u2010sided lateralization effect and was especially marked in the posterior insula, a region associated with visceral information processing and the embodiment effect of a substance, from which craving arises. Anatomical damages might thus underlie the previously reported altered insular activations and their behavioural counterparts.<\/jats:p>","DOI":"10.1111\/adb.13324","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T10:37:58Z","timestamp":1693564678000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Insular volumetry in severe alcohol use disorder and Korsakoff's syndrome through an anatomical parcellation: Let us go back to basics"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6955-3672","authenticated-orcid":false,"given":"Pauline","family":"Billaux","sequence":"first","affiliation":[{"name":"Louvain Experimental Psychopathology research group (LEP), Psychological Science Research Institute UCLouvain  Louvain\u2010la\u2010Neuve 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