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Cyclin\u2010dependent kinase 5 (Cdk5), a neuronal serine\/threonine protein kinase that plays a role in multiple neuronal functions, has been demonstrated to be involved in drug addiction and learning and memory. Here, we aimed to investigate the role of cdk5 activity in the basolateral amygdala (BLA) in relapse to heroin seeking, using a self\u2010administration rat model. Male rats underwent 10\u00a0days of heroin self\u2010administration training, during which an active nose poke resulted in an intravenous infusion of heroin that was accompanied by a cue. The rats then underwent nose poke extinction for 10\u00a0days, followed by subsequent tests of heroin\u2010seeking behaviour. We found that intra\u2010BLA infusion of \u03b2\u2010butyrolactone (100\u2009ng\/side), a Cdk5 inhibitor, administered 5\u2009min after reactivation, led to a subsequent decrease in heroin\u2010seeking behaviour. Further experiments demonstrated that the effects of \u03b2\u2010butyrolactone are dependent on reactivated memories, temporal\u2010specific and long\u2010lasting on relapse of heroin\u2010associated memory. Results provide suggestive evidence that the activity of Cdk5 in BLA is critical for heroin\u2010associated memory and that the specific inhibitor, \u03b2\u2010butyrolactone, may hold potential as a substance for the treatment of heroin abuse.<\/jats:p>","DOI":"10.1111\/adb.13326","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T20:46:54Z","timestamp":1692650814000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Cdk5 inhibitor \u03b2\u2010butyrolactone impairs reconsolidation of heroin\u2010associated memory in the rat basolateral amygdala"],"prefix":"10.1111","volume":"28","author":[{"given":"Haoyu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Xiangya Hospital Central South University  Changsha China"},{"name":"The Institute of Skull Base Surgery and Neurooncology at Hunan Province  Changsha China"},{"name":"National Clinical 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