{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:53:05Z","timestamp":1777917185190,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:00:00Z","timestamp":1694995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["F32 DA036319"],"award-info":[{"award-number":["F32 DA036319"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["K12 HD055885"],"award-info":[{"award-number":["K12 HD055885"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["F32 DA047845"],"award-info":[{"award-number":["F32 DA047845"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["T32 DA007288"],"award-info":[{"award-number":["T32 DA007288"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01 DA027664"],"award-info":[{"award-number":["R01 DA027664"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01 DA032708"],"award-info":[{"award-number":["R01 DA032708"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["P50 DA046373"],"award-info":[{"award-number":["P50 DA046373"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Use of addictive substances like cocaine produces enduring associations between the drug experience and cues in the drug\u2010taking environment. In individuals with a substance use disorder (SUD) and attempting to remain abstinent, these powerful drug\u2010cue associations can trigger a return to active drug use, but the molecular mechanisms regulating drug\u2010cue associations remain poorly understood. The activity\u2010regulated cytoskeleton\u2010associated protein (Arc) is induced by cocaine in the nucleus accumbens (NAc), an important brain reward region, but Arc's NAc function in SUD\u2010related behaviour remains unclear. We show here that cocaine self\u2010administration (SA) in rats produced a significant upregulation of Arc protein in both the core and shell subregions of the NAc. Subregion\u2010specific Arc reduction (shRNA) in the medial NAc Shell enhanced both context\u2010associated and cue\u2010reinstated cocaine seeking, but without altering the motivation to work for cocaine, the sensitivity to the reinforcing effects of cocaine or the ability of cocaine priming to reinstate drug seeking. In contrast, we observed no effects of Arc knockdown in the NAc core on any aspect of cocaine SA, extinction or reinstated cocaine seeking, suggesting that Arc functions within the medial NAc shell, but not NAc core, to limit the strength of drug\u2010context and drug\u2010cue associations that promote cocaine\u2010seeking behaviour.<\/jats:p>","DOI":"10.1111\/adb.13335","type":"journal-article","created":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T07:38:40Z","timestamp":1695022720000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The activity\u2010regulated cytoskeleton\u2010associated protein, Arc, functions in the nucleus accumbens shell to limit multiple triggers of cocaine\u2010seeking behaviour"],"prefix":"10.1111","volume":"28","author":[{"given":"Sarah M.","family":"Barry","sequence":"first","affiliation":[{"name":"Department of Neuroscience Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella M.","family":"Barry","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalia","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel D.","family":"Penrod","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5472-3296","authenticated-orcid":false,"given":"Christopher W.","family":"Cowan","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2515"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.01.017"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5457\u201008.2009"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.318"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2007.05692.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23\u201008\u201003531.2003"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12043"},{"key":"e_1_2_10_9_1","unstructured":"PascoliV TerrierJ EspallerguesJ ValjentE O'ConnorEC L\u00fcscherC.Contrasting forms of cocaine\u2010evoked plasticity control components of relapse.2014;1\u201318.10.1038\/nature13257"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.12.5734"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896\u20106273(95)90299\u20106"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.08.034"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.09.031"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.08.033"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1067\u201010.2010"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12561"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/16046"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.05.023"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.05.014"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145710001173"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471\u20104159.1995.64052377.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.106.026302"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2708"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.05.025"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2019.172818"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.114"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142301.ns0437s73"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010008\u20101090\u20102"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471\u20104159.2000.0742074.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4342\u201004.2005"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.045013.117"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1120\u201011.2011"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14084"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2004.06.006"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386\u2010018\u20100305\u20104"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2277\u201012.2012"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01249"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.81404"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.0773\u201016.2016"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010004\u20101895\u20106"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.1570\u201013.2013"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1291\u201015.2016"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyx107"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.04.004"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.4.1976"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010006\u20100578\u2010x"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744\u20109081\u20106\u201024"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20502"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072883"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.13335","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T08:12:36Z","timestamp":1695802356000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adb.13335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,18]]},"references-count":48,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/adb.13335"],"URL":"https:\/\/doi.org\/10.1111\/adb.13335","archive":["Portico"],"relation":{},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,18]]},"assertion":[{"value":"2023-03-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13335"}}