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Despite public emphasis on overdose fatalities, most overdose cases are not fatal. Although there are case reports of amnestic syndromes and acute injury to the hippocampus following non\u2010fatal opioid overdose, the effects of such overdoses on brain structure are poorly understood. Here, we investigated the neuroanatomical correlates of non\u2010fatal opioid overdoses by comparing hippocampal volume in opioid use disorder (OUD) patients who had experienced an opioid overdose (OD;\n                    <jats:italic>N<\/jats:italic>\n                    \u00a0=\u200917) with those who had not (NOD;\n                    <jats:italic>N<\/jats:italic>\n                    \u00a0=\u200932). Voxel\u2010based morphometry showed lower hippocampal volume in the OD group than in the NOD group, which on post hoc analysis was evident in the left but not the right hippocampus. These findings strengthen the evidence that hippocampal injury is associated with non\u2010fatal opioid overdose, which is hypothesized to underlie overdose\u2010related amnestic syndrome.\n                  <\/jats:p>","DOI":"10.1111\/adb.13336","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T11:29:01Z","timestamp":1695209341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Hippocampal volume loss in individuals with a history of non\u2010fatal opioid overdose"],"prefix":"10.1111","volume":"28","author":[{"given":"Dustin R.","family":"Todaro","sequence":"first","affiliation":[{"name":"Center for Studies of Addiction, Department of Psychiatry, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Li","sequence":"additional","affiliation":[{"name":"Center for 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