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However, whether resting vagally\u2010mediated heart rate variability (HRV) exerting influences on the association of IAT and brain morphology remains unclear. This study used voxel\u2010based morphometry (VBM) and multiple regression analyses to assess the interaction effect of IAT and resting vagally\u2010mediated HRV on regional grey matter volumes in 82 healthy subjects. To further illustrate the observed interaction effect, the moderated hierarchical regression analysis was performed. The results showed that resting vagally\u2010mediated HRV moderated the relationship between IAT scores and grey matter volume (GMV) in the precuneus and cerebellum. Specifically, individuals with higher resting vagally\u2010mediated HRV showed a significant positive relationship between IAT scores and GMV in the precuneus, whereas individuals with lower resting vagally\u2010mediated HRV showed a significant negative relationship between IAT scores and GMV in the precuneus. In addition, IAT scores were negatively correlated with GMV in the cerebellum among individuals with lower resting vagally\u2010mediated HRV, but not among individuals with higher resting vagally\u2010mediated HRV. These findings have demonstrated a moderating role of resting vagally\u2010mediated HRV on the association of IAT and brain morphology.<\/jats:p>","DOI":"10.1111\/adb.13340","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T03:59:45Z","timestamp":1697083185000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The moderating effect of resting heart rate variability on the relationship between internet addiction tendency and brain morphology"],"prefix":"10.1111","volume":"28","author":[{"given":"Yuandong","family":"Zeng","sequence":"first","affiliation":[{"name":"School of Psychology Jiangxi Normal University  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4918-3955","authenticated-orcid":false,"given":"Guo\u2010Rong","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cognition and 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