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The differences of functional and structural connectivity were found among several brain regions such as thalamus and frontal lobe. However, few studies focused on functional connectivity (FC) in whole\u2010brain voxel level of young smokers. In this study, intrinsic connectivity contrast (ICC) was used to perform voxel\u2010based whole\u2010brain analyses in 55 young smokers and 55 matched non\u2010smokers to identify brain regions with significant group differences. ICC results showed that the connectivity of young smokers in medial frontal cortex (MedFC), supramarginal gyrus anterior division left (L_aSMG), central opercular cortex left (L_CO) and middle frontal gyrus left (L_MidFG) showed a significantly lower trend compared with the non\u2010smokers. The seed\u2010based FC analysis about MedFC indicated that young smokers showed reduced connectivity between the MedFC and left hippocampus, left amygdala compared to non\u2010smokers. Correlation analysis showed that the ICC of MedFC in young smokers was significantly negatively correlated with Fagerstrom test for nicotine dependence (FTND) and Questionnaire on Smoking Urges (QSU). The FC between the MedFC and left hippocampus, left amygdala was significantly negatively correlated with Pack_years. The mediation analysis indicated that ICC of MedFC completely mediated FTND and QSU of young smokers. The results suggest that nicotine accumulation may affect the communication of the frontal lobe with the whole brain to some extent, leading to changes in smoking cravings. The above research also provides in\u2010depth insights into the mechanism of adolescent smoking addiction and related intervention treatment.<\/jats:p>","DOI":"10.1111\/adb.13347","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T16:12:03Z","timestamp":1698423123000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The changes of intrinsic connectivity contrast in young smokers"],"prefix":"10.1111","volume":"28","author":[{"given":"Yang","family":"Zhou","sequence":"first","affiliation":[{"name":"Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing, School of Information Engineering Inner Mongolia University of Science and Technology  Baotou Inner Mongolia China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Xue","sequence":"additional","affiliation":[{"name":"Inner Mongolia Key Laboratory of Pattern Recognition 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