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Previous studies on abnormal anatomical patterns in CUD have mainly used voxel\u2010based morphometry to investigate grey matter volume changes, while surface\u2010based morphometry (SBM) has been found to provide detail information on cortical thickness (CT), surface area and cortical meancurve, which can contribute to a better understanding of structural brain changes associated with CUD. In this study, SBM was conducted to investigate abnormal neuroanatomical patterns in CUD and whether these abnormal patterns could be used as potential diagnostic biomarkers for CUD. Sixty\u2010eight CUD individuals and 52 matched healthy controls were enrolled, and all participants performed once MRI scanning and clinical assessments. We found that CUD individuals exhibited altered morphological indicators across widespread brain regions and these abnormal anatomical alterations were significantly predictive of CUD status. Furthermore, the CT reduction of right insula was significantly associated with years of cocaine use in CUD. These findings revealed the association of abnormal anatomical patterns in specific brain regions in CUD, which further improve the understanding of CUD pathophysiology and provide the alternative diagnostic biomarkers for CUD.<\/jats:p>","DOI":"10.1111\/adb.13348","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T12:44:25Z","timestamp":1697114665000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Abnormal neuroanatomical patterns as potential diagnostic biomarkers for cocaine use disorder"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4514-0413","authenticated-orcid":false,"given":"Hui","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou China"},{"name":"School of Mental Health Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Psychology and Cognitive Science East China Normal University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyu","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yike","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghui","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou 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