{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T04:18:33Z","timestamp":1772857113108,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:00:00Z","timestamp":1699920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["NP\u2010109\u2010PP\u201005"],"award-info":[{"award-number":["NP\u2010109\u2010PP\u201005"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 110\u20102314\u2010B\u2010400\u2010027\u2010MY3"],"award-info":[{"award-number":["MOST 110\u20102314\u2010B\u2010400\u2010027\u2010MY3"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Conditioned place preference (CPP) paradigm in zebrafish has been used to measure drug reward, but there is limited research on CPP reinstatement to determine relapse vulnerability. The present study aimed to investigate extinction and reinstatement of methamphetamine (MA)\u2010induced CPP in zebrafish and evaluate the model's predictive validity. Zebrafish received different doses of MA (0\u201360\u2009mg\/kg) during CPP training. The preferred dose of MA at 40\u2009mg\/kg was used for extinction via either confined or nonconfined procedures. The extinguished CPP was reinstated by administering a priming dose of MA (20\u2009mg\/kg) or various stressors. To assess persistent susceptibility to reinstatement, MA CPP and reinstatement were retested following 14\u2009days of abstinence. In addition, the effects of SCH23390, naltrexone, and clonidine on MA CPP during acquisition, expression, or reinstatement phases were monitored. MA induced CPP in a dose\u2010dependent manner. Both nonconfined and confined extinction procedures time\u2010dependently reduced the time spent on the MA\u2010paired side. A priming dose of MA, chasing stress, or yohimbine reinstated the extinguished CPP. After 14\u2009days of abstinence, the MA CPP remained extinguished and was significantly reinstated by MA priming or chasing stress. Similar to the observations in rodents, SCH23390 suppressed the acquisition of MA CPP, naltrexone reduced the expression and MA priming\u2010induced reinstatement, while clonidine prevented stress\u2010induced reinstatement of MA CPP. This work expanded the zebrafish CPP paradigm to include extinction and reinstatement phases, demonstrating predictive validity and highlighting its potential as a valuable tool for exploring drug relapse.<\/jats:p>","DOI":"10.1111\/adb.13351","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T14:33:04Z","timestamp":1699972384000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Extinction and reinstatement of methamphetamine\u2010induced conditioned place preference in zebrafish"],"prefix":"10.1111","volume":"28","author":[{"given":"Liao\u2010Chen","family":"Chen","sequence":"first","affiliation":[{"name":"Center for Neuropsychiatric Research National Health Research Institutes  Zhunan Taiwan"},{"name":"Institute of Systems Neuroscience, College of Life Science and Medicine National Tsing Hua University  Hsinchu Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Huan","family":"Chan","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience National Chengchi University  Taipei City Taiwan"},{"name":"Research Center for Mind, Brain, and Learning National Chengchi University  Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8509-6448","authenticated-orcid":false,"given":"Hwei\u2010Hsien","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Neuropsychiatric Research National Health Research Institutes  Zhunan Taiwan"},{"name":"Institute of Systems Neuroscience, College of Life Science and Medicine National Tsing Hua University  Hsinchu Taiwan"},{"name":"Institute of Neuroscience National Chengchi University  Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369\u20101600.2007.00070.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2020.582147"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166\u20104328(00)00239\u20104"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2008.154"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.142"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13754"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2016.03.004"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069453"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.014399"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2005.12.007"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2003.08.054"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4172\/2155\u20106105.s1\u2010003"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.29252\/nirp.bcn.9.3.157"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2009.08.035"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1037\/bne0000005"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103232"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2019.02.006"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2021.108681"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20108993(91)90990\u2010D"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.02.032"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210\u2010019\u201001694\u20103"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2020.112971"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460\u20109568.2000.00899.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893\u2010133X(99)00158\u2010X"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2010.09.013"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3791\/50691\u2010v"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.024166"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2010.201"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034992"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.7469"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.1413"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e328363d14a"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2014.05.014"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u201060761\u2010953\u20106_6"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010020\u201002260\u20102"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2021.108717"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfb.15453"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.86"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0742\u20108413(98)00037\u20101"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.13351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T10:44:03Z","timestamp":1702723443000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adb.13351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,14]]},"references-count":39,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/adb.13351"],"URL":"https:\/\/doi.org\/10.1111\/adb.13351","archive":["Portico"],"relation":{},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,14]]},"assertion":[{"value":"2023-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13351"}}