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Few studies have investigated the inflammatory response of patients with methamphetamine\u2010induced psychotic disorder. Clinically, the psychotic symptoms and behavioural manifestation of methamphetamine\u2010induced psychotic disorder are often indistinguishable from paranoid schizophrenia. We aimed to determine the differences in these inflammatory markers between patients with methamphetamine\u2010induced psychotic disorder, patients with schizophrenia and healthy individuals. A total of 905 individuals were recruited. The NLR and MLR were found to be higher in both patients with methamphetamine\u2010induced psychotic disorders and patients with schizophrenia compared with healthy controls. There was no significant difference between the three groups in PLR. When compared with the control group, the methamphetamine\u2010induced psychotic disorder group was significantly higher in NLR 27% (95%CI\u2009=\u200911 to 46%, <jats:italic>p<\/jats:italic>\u2009=\u20090.001), MLR 16% (95%CI\u2009=\u20093% to 31%, <jats:italic>p<\/jats:italic>\u2009=\u20090.013) and PLR 16% (95%CI\u2009=\u20095% to 28%, <jats:italic>p<\/jats:italic>\u2009=\u20090.005). NLR of the group with methamphetamine\u2010induced psychotic disorder was 17% (95%CI\u2009=\u200973% to 94%, <jats:italic>p<\/jats:italic>\u2009=\u20090.004) less than the group with schizophrenia, while MLR and PLR did not differ significantly between the two groups. This is the first study that investigated the lymphocyte\u2010related ratios in methamphetamine\u2010induced psychotic disorder when compared with patients with schizophrenia and healthy individuals. The results showed that both patients with methamphetamine\u2010induced psychotic disorder and patients with schizophrenia had stronger inflammatory responses than the healthy control. Our finding also indicated that the inflammatory response of methamphetamine\u2010induced psychotic disorder was between those of patients with schizophrenia and healthy individuals.<\/jats:p>","DOI":"10.1111\/adb.13363","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T13:49:27Z","timestamp":1706536167000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Lymphocyte\u2010related ratios in methamphetamine\u2010induced psychotic disorder in Taiwan, comparing with patients with schizophrenia"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7639-573X","authenticated-orcid":false,"given":"Mei\u2010Hing","family":"Ng","sequence":"first","affiliation":[{"name":"Institute of Medicine Chung Shan Medical University  Taichung Taiwan"},{"name":"Tsaotun Psychiatric Center Ministry of Health and Welfare  Nantou County Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mong\u2010Liang","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Wan\u2010Fang Hospital &amp; School of Medicine College of Medicine Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent Chin\u2010Hung","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Chang Gung Medical Foundation Chiayi Chang Gung Memorial Hospital  Chiayi County Taiwan"},{"name":"Department of Psychiatry School of Medicine Chang Gung University  Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Ting","sequence":"additional","affiliation":[{"name":"Institute of Medicine Chung Shan Medical University  Taichung Taiwan"},{"name":"Department of Physical Medicine and Rehabilitation Chung\u2010Shan Medical, University Hospital Chung\u2010Shan Medical University  Taichung 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