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However, the abuse potential of <jats:italic>N<\/jats:italic>\u2010ipb remains unclear. Therefore, this study aimed to evaluate the abuse potential of <jats:italic>N<\/jats:italic>\u2010ipb in comparison to METH, by using conditioned place preference (CPP), locomotor sensitization and intravenous self\u2010administration tests. The results showed that <jats:italic>N<\/jats:italic>\u2010ipb at a dose of 3\u2009mg\u00b7kg<jats:sup>\u22121<\/jats:sup> significantly induced CPP in mice, which was comparable to the effect of METH at 1\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup>. Either acute or repeated <jats:italic>N<\/jats:italic>\u2010ipb injections (1 or 3\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup>) failed to raise the locomotor activity. However, acute treatment with 10\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup> <jats:italic>N<\/jats:italic>\u2010ipb elevated the locomotor activity compared with saline, while chronic injection of 10\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup> <jats:italic>N<\/jats:italic>\u2010ipb induced a delayed and attenuated sensitization compared with 1\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup> METH. Rats could acquire <jats:italic>N<\/jats:italic>\u2010ipb self\u2010administration at a dose of 1\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7infusion<jats:sup>\u22121<\/jats:sup>, and a typical inverted U\u2010shaped dose\u2013response curve was obtained for <jats:italic>N<\/jats:italic>\u2010ipb. The mean dose of <jats:italic>N<\/jats:italic>\u2010ipb that maintained the maximum response was greater than that of METH, indicating that <jats:italic>N<\/jats:italic>\u2010ipb is less potent for reinforcement than METH. In the economic behavioural analysis, comparison of essential values derived from the demand elasticity revealed that <jats:italic>N<\/jats:italic>\u2010ipb is less efficacy as a reinforcer than METH. The present data demonstrate that <jats:italic>N<\/jats:italic>\u2010ipb functions as a reinforcer and has a potential for abuse. However, the potency of psychomotor stimulation and the reinforcing effectiveness of <jats:italic>N<\/jats:italic>\u2010ipb are lower than those of METH.<\/jats:p>","DOI":"10.1111\/adb.13370","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T09:19:51Z","timestamp":1707902391000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>N<\/i>\u2010Isopropylbenzylamine\u2010induced conditioned place preference, sensitization behaviour and self\u2010administration in rodents"],"prefix":"10.1111","volume":"29","author":[{"given":"Miaojun","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Psychiatry Affiliated Kangning Hospital of Ningbo University  Ningbo China"},{"name":"Key Laboratory of Addiction Research of Zhejiang Province  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Affiliated Kangning Hospital of Ningbo University  Ningbo China"},{"name":"Key Laboratory of Addiction Research of Zhejiang Province  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Li","sequence":"additional","affiliation":[{"name":"Office of China National Narcotics Control Commission China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control  Beijing China"},{"name":"Key Laboratory of Drug Monitoring and Control, Drug Intelligence and Forensic Center Ministry of Public Security  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingding","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Affiliated Kangning Hospital of Ningbo University  Ningbo China"},{"name":"Key Laboratory of Addiction Research of Zhejiang Province  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Affiliated Kangning Hospital of Ningbo University  Ningbo China"},{"name":"Key Laboratory of Addiction Research of Zhejiang Province  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeming","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Affiliated Kangning Hospital of Ningbo University  Ningbo China"},{"name":"Key Laboratory of Addiction Research of Zhejiang Province  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Affiliated Kangning Hospital of Ningbo University  Ningbo China"},{"name":"Key Laboratory of Addiction Research of Zhejiang Province  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haowei","family":"Shen","sequence":"additional","affiliation":[{"name":"Faculty of Physiology &amp; 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