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The current study investigated the impact of spontaneous withdrawal from chronic morphine exposure on emotional, motivational and cognitive processes involved in regulating the pursuit and consumption of food rewards in male rats. In Experiment 1, rats experiencing acute morphine withdrawal lost weight and displayed somatic signs of drug dependence. However, hedonically driven sucrose consumption was significantly elevated, suggesting intact and potentially heightened reward processing. In Experiment 2, rats undergoing acute morphine withdrawal displayed reduced motivation when performing an effortful response for palatable food reward. Subsequent reward devaluation testing revealed that acute withdrawal disrupted their ability to exert flexible goal\u2010directed control over reward seeking. Specifically, morphine\u2010withdrawn rats were impaired in using current reward value to select actions both when relying on prior action\u2010outcome learning and when given direct feedback about the consequences of their actions. In Experiment 3, rats tested after prolonged morphine withdrawal displayed heightened rather than diminished motivation for food rewards and retained their ability to engage in flexible goal\u2010directed action selection. However, brief re\u2010exposure to morphine was sufficient to impair motivation and disrupt goal\u2010directed action selection, though in this case, rats were only impaired in using reward value to select actions in the presence of morphine\u2010paired context cues and in the absence of response\u2010contingent feedback. We suggest that these opioid\u2010withdrawal induced deficits in motivation and goal\u2010directed control may contribute to addiction by interfering with the pursuit of adaptive alternatives to drug use.<\/jats:p>","DOI":"10.1111\/adb.13393","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T03:54:17Z","timestamp":1714967657000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Differential effects of acute and prolonged morphine withdrawal on motivational and goal\u2010directed control over reward\u2010seeking behaviour"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6128-2601","authenticated-orcid":false,"given":"Briac","family":"Halbout","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Perioperative Care, School of Medicine University of California, Irvine  Irvine California 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