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We have recently shown that neuronal ensembles in the prelimbic cortex form rapidly to mediate cocaine self\u2010administration. However, the role of neuronal ensembles within the nucleus accumbens in initial cocaine\u2010seeking behaviour remains unknown. Here, we sought to expand the current literature by testing the necessity of the cocaine self\u2010administration ensemble in the nucleus accumbens core (NAcCore) 1\u2009day after male and female rats acquire cocaine self\u2010administration by using the Daun02 inactivation procedure. We found that disrupting the NAcCore ensembles after a no\u2010cocaine reward\u2010seeking test increased subsequent cocaine seeking, while disrupting NAcCore ensembles following a cocaine self\u2010administration session decreased subsequent cocaine seeking. We then characterized neuronal cell type in the NAcCore using RNAscope in situ hybridization. In the no\u2010cocaine session, we saw reduced dopamine D1 type neuronal activation, while in the cocaine self\u2010administration session, we found preferential dopamine D1 type neuronal activity in the NAcCore.<\/jats:p>","DOI":"10.1111\/adb.13397","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T04:38:51Z","timestamp":1715056731000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Nucleus accumbens neuronal ensembles vary with cocaine reinforcement in male and female rats"],"prefix":"10.1111","volume":"29","author":[{"given":"Bo W.","family":"Sortman","sequence":"first","affiliation":[{"name":"Department of Pharmacodynamics University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Rakela","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics University of Florida  Gainesville 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