{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:41:32Z","timestamp":1793227292290,"version":"4.5.0"},"reference-count":65,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Substance use disorders (SUDs) are seen as a continuum ranging from goal\u2010directed and hedonic drug use to loss of control over drug intake with aversive consequences for mental and physical health and social functioning. The main goals of our interdisciplinary German collaborative research centre on <jats:italic>Losing and Regaining Control over Drug Intake<\/jats:italic> (ReCoDe) are (i) to study triggers (drug cues, stressors, drug priming) and modifying factors (age, gender, physical activity, cognitive functions, childhood adversity, social factors, such as loneliness and social contact\/interaction) that longitudinally modulate the trajectories of losing and regaining control over drug consumption under real\u2010life conditions. (ii) To study underlying behavioural, cognitive and neurobiological mechanisms of disease trajectories and drug\u2010related behaviours and (iii) to provide non\u2010invasive mechanism\u2010based interventions. These goals are achieved by: (A) using innovative mHealth (mobile health) tools to longitudinally monitor the effects of triggers and modifying factors on drug consumption patterns in real life in a cohort of 900 patients with alcohol use disorder. This approach will be complemented by animal models of addiction with 24\/7 automated behavioural monitoring across an entire disease trajectory; i.e. from a na\u00efve state to a drug\u2010taking state to an addiction or resilience\u2010like state. (B) The identification and, if applicable, computational modelling of key molecular, neurobiological and psychological mechanisms (e.g., reduced cognitive flexibility) mediating the effects of such triggers and modifying factors on disease trajectories. (C) Developing and testing non\u2010invasive interventions (e.g., Just\u2010In\u2010Time\u2010Adaptive\u2010Interventions (JITAIs), various non\u2010invasive brain stimulations (NIBS), individualized physical activity) that specifically target the underlying mechanisms for regaining control over drug intake. Here, we will report on the most important results of the first funding period and outline our future research strategy.<\/jats:p>","DOI":"10.1111\/adb.13419","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T12:00:33Z","timestamp":1719835233000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["The ReCoDe addiction research consortium: Losing and regaining control over drug intake\u2014Findings and future perspectives"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2151-4521","authenticated-orcid":false,"given":"Rainer","family":"Spanagel","sequence":"first","affiliation":[{"name":"Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University  Mannheim Germany"},{"name":"German Center for Mental Health (DZPG), Partner Site Mannheim\u2010Heidelberg\u2010Ulm  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