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Most drug\u2010seeking behaviours that can be modelled in rodents utilize the repeated intravenous self\u2010administration (SA) of drugs. Recent studies examining the mesolimbic pathway suggest that K\n                    <jats:sub>v<\/jats:sub>\n                    7\/KCNQ channels may contribute to the transition from recreational to chronic drug use. However, to date, all such studies used noncontingent, experimenter\u2010delivered drug model systems, and the extent to which this effect generalizes to rats trained to self\u2010administer drugs is not known. Here, we tested the ability of retigabine (ezogabine), a K\n                    <jats:sub>v<\/jats:sub>\n                    7 channel opener, to regulate instrumental behaviour in male Sprague Dawley rats. We first validated the ability of retigabine to target experimenter\u2010delivered cocaine in a conditioned place preference (CPP) assay and found that retigabine reduced the acquisition of place preference. Next, we trained rats for cocaine\u2010SA under a fixed\u2010ratio or progressive\u2010ratio reinforcement schedule and found that retigabine pretreatment attenuated the SA of low to moderate doses of cocaine. This was not observed in parallel experiments, with rats self\u2010administering sucrose, a natural reward. Compared with sucrose\u2010SA, cocaine\u2010SA was associated with reductions in the expression of the K\n                    <jats:sub>v<\/jats:sub>\n                    7.5 subunit in the nucleus accumbens, without alterations in K\n                    <jats:sub>v<\/jats:sub>\n                    7.2 and K\n                    <jats:sub>v<\/jats:sub>\n                    7.3. Therefore, these studies reveal a reward\u2010specific reduction in SA behaviour and support the notion that K\n                    <jats:sub>v<\/jats:sub>\n                    7 is a potential therapeutic target for human psychiatric diseases with dysfunctional reward circuitry.\n                  <\/jats:p>","DOI":"10.1111\/adb.13428","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T09:41:36Z","timestamp":1722505296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["K\n                    <sub>v<\/sub>\n                    7 channel opener retigabine reduces self\u2010administration of cocaine but not sucrose in rats"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1283-024X","authenticated-orcid":false,"given":"Esteban S.","family":"Urena","sequence":"first","affiliation":[{"name":"Department of Pharmacology, College of Medicine 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University of Arizona  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara R.","family":"Barber","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Medicine University of Arizona  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd W.","family":"Vanderah","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Medicine University of Arizona  Tucson Arizona USA"},{"name":"Neuroscience Graduate Interdisciplinary Program University of Arizona  Tucson Arizona USA"},{"name":"Comprehensive Pain and Addiction\u2010Center (CPA\u2010C) University of Arizona Health Sciences  Tucson Arizona USA"},{"name":"The Center of Excellence in Addiction Studies (CEAS) University of Arizona  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7758-4436","authenticated-orcid":false,"given":"Arthur 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