{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T06:02:12Z","timestamp":1793426532837,"version":"4.5.0"},"reference-count":72,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["K23AA028238"],"award-info":[{"award-number":["K23AA028238"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01 AA027765"],"award-info":[{"award-number":["R01 AA027765"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01 AA026859"],"award-info":[{"award-number":["R01 AA026859"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R21 AA031146"],"award-info":[{"award-number":["R21 AA031146"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["P50 DA056408"],"award-info":[{"award-number":["P50 DA056408"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alcohol exposure affects brain structure, but the extent to which its effects differ across development remains unclear. Several countries are considering changes to recommended guidelines for alcohol consumption, so high\u2010quality evidence is needed. Many studies have been conducted among small samples, but recent efforts have been made to acquire large samples to characterize alcohol's effects on the brain on a population level. Several large\u2010scale consortia have acquired such samples, but this evidence has not been synthesized across the lifespan. We conducted a systematic review of large\u2010scale neuroimaging studies examining effects of alcohol exposure on brain structure at multiple developmental stages. We included studies with an alcohol\u2010exposed sample of at least <jats:italic>N<\/jats:italic>\u2009=\u2009100 from the following consortia: ABCD, ENIGMA, NCANDA, IMAGEN, Framingham Offspring Study, HCP and UK BioBank. Twenty\u2010seven studies were included, examining prenatal (<jats:italic>N<\/jats:italic>\u2009=\u20091), adolescent (<jats:italic>N<\/jats:italic>\u2009=\u20099), low\u2010to\u2010moderate\u2010level adult (<jats:italic>N<\/jats:italic>\u2009=\u200911) and heavy adult (<jats:italic>N<\/jats:italic>\u2009=\u20097) exposure. Prenatal exposure was associated with greater brain volume at ages 9\u201310, but contemporaneous alcohol consumption during adolescence and adulthood was associated with smaller volume\/thickness. Both low\u2010to\u2010moderate consumption and heavy consumption were characterized by smaller volume and thickness in frontal, temporal and parietal regions, and reductions in insula, cingulate and subcortical structures. Adolescent consumption had similar effects, with less consistent evidence for smaller cingulate, insula and subcortical volume. In sum, prenatal exposure was associated with larger volume, while adolescent and adult alcohol exposure was associated with smaller volume and thickness, suggesting that regional patterns of effects of alcohol are similar in adolescence and adulthood.<\/jats:p>","DOI":"10.1111\/adb.13439","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T12:21:27Z","timestamp":1727266887000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Alcohol and brain structure across the lifespan: A systematic review of large\u2010scale neuroimaging studies"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1232-1202","authenticated-orcid":false,"given":"Hollis C.","family":"Karoly","sequence":"first","affiliation":[{"name":"Department of Psychology Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4106-2526","authenticated-orcid":false,"given":"Katelyn T.","family":"Kirk\u2010Provencher","sequence":"additional","affiliation":[{"name":"Department of Radiology, School of Medicine University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4250-0495","authenticated-orcid":false,"given":"Joseph P.","family":"Schacht","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9016-6973","authenticated-orcid":false,"given":"Joshua L.","family":"Gowin","sequence":"additional","affiliation":[{"name":"Department of Radiology, School of Medicine University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(09)60746\u20107"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)31310\u20102"},{"key":"e_1_2_9_4_1","unstructured":"SAMHSA.Center for Behavioral Health Statistics and Quality. 2022 National Survey on Drug Use and Health. Table 2.25B\u2014alcohol use in lifetime: among people aged 12 or older; by age group and demographic characteristics percentages 2021 and 202. Accessed December 28 2023.https:\/\/www.samhsa.gov\/data\/sites\/default\/files\/reports\/rpt42728\/NSDUHDetailedTabs2022\/NSDUHDetailedTabs2022\/NSDUHDetTabsSect2pe2022.htm"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2019.6235"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402680101"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23604"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/62.5.486"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agn079"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530\u20100277.2003.tb04415.x"},{"issue":"2","key":"e_1_2_9_11_1","first-page":"143","article-title":"Hepatic encephalopathy\u2014a serious complication of alcoholic liver disease","volume":"27","author":"Butterworth RF","year":"2003","journal-title":"Alcohol Res Health"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201004492\u20109"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.16316"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2018.03.001"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.2015.76.895"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25311"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010020\u20100822\u20105"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.570044"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROBIOLAGING.2020.03.014"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4361"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2021.105906"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888\u2010021\u201003244\u20109"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.03.034"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.4135\/9781483398761"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.16001"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/ADD.15772"},{"key":"e_1_2_9_27_1","volume-title":"American Drinking Practices: A National Survey of Behavior and Attitudes","author":"Cahalan D","year":"1969"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1176\/APPI.AJP.2020.20010086"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/ADB.13208"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhab368"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010021\u201001275\u20100"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOPSYCH.2019.08.026"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.17040469"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/CERCOR\/BHV205"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41386\u2010022\u201001457\u20104"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMAPSYCHIATRY.2019.4063"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.10.1363"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/ACER.14147"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NICL.2020.102529"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201028735\u20105"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/CERCOR\/BHY300"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOPSYCH.2022.03.008"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ALCOHOL.2019.11.002"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201056089\u20104"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2019.06.005"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NICL.2022.103066"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.7554\/ELIFE.65325"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/HBM.25114"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2021.102636"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1176\/APPI.AJP.2018.17040415"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41398\u2010021\u201001204\u20101"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/ADB.12830"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NICL.2021.102866"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROIMAGE.2016.01.061"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21260"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.72"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214\u2010109X(17)30021\u20109"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2024.05.008"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.07.002"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhu239"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq297"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.115"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3479\u201008.2008"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.7.989"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2014.02.004"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2018.0021"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2004.11.004"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2007.05.027"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12848"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2022.06.002"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2019.08.029"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2014.187"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956797620916786"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.13439","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T15:35:21Z","timestamp":1732894521000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adb.13439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":72,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/adb.13439"],"URL":"https:\/\/doi.org\/10.1111\/adb.13439","archive":["Portico"],"relation":{},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"2024-02-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13439"}}