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Yet, little is known regarding the neural dysfunctions accompanying these difficulties. Here, we acquired cross\u2010sectional, functional magnetic resonance imaging while people with problematic methamphetamine\u2010use experience (MA<jats:sup>+<\/jats:sup>, <jats:italic>n\u2009=<\/jats:italic>\u00a065) and people without methamphetamine\u2010use experience (MA<jats:sup>\u2212<\/jats:sup>, <jats:italic>n\u2009=<\/jats:italic>\u00a044) performed a parametric <jats:italic>n<\/jats:italic>\u2010back task (0\u2010back through 2\u2010back). Performance on tasks administered outside of the scanner, together with <jats:italic>n<\/jats:italic>\u2010back performance, afforded to determine a latent dimension of participants' working memory ability. Behavioural results indicated that MA<jats:sup>+<\/jats:sup> participants exhibited lower scores on this dimension compared to MA<jats:sup>\u2212<\/jats:sup> participants (<jats:italic>d\u2009=<\/jats:italic>\u2009\u22121.39, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Whole\u2010brain imaging results also revealed that MA<jats:sup>+<\/jats:sup> participants exhibited alterations in load\u2010induced responses predominantly in frontoparietal and default\u2010mode areas. Specifically, while the MA<jats:sup>\u2212<\/jats:sup> group exhibited monotonic activation increases within frontoparietal areas and monotonic decreases within default\u2010mode areas from 0\u2010back to 2\u2010back, MA<jats:sup>+<\/jats:sup> participants showed a relative attenuation of these load\u2010induced activation patterns (<jats:italic>d<\/jats:italic>\u2009=\u2009\u22121.55, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Moreover, increased activations in frontoparietal areas from 0\u2010 to 2\u2010back were related to greater working memory ability among MA<jats:sup>+<\/jats:sup> participants (<jats:italic>r<\/jats:italic>\u2009=\u2009.560, <jats:italic>p<\/jats:italic>\u2009=\u2009.004). No such effects were observed for default\u2010mode areas. In sum, reductions in working memory ability were observed alongside load\u2010induced dysfunctions in frontoparietal and default\u2010mode areas for people with problematic methamphetamine\u2010use experience. Among them, load\u2010induced activations within frontoparietal areas were found to have a strong and specific relationship to individual differences in working memory ability, indicating a putative neural signature of the working memory difficulties associated with chronic methamphetamine use.<\/jats:p>","DOI":"10.1111\/adb.13444","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T08:43:29Z","timestamp":1729068209000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Methamphetamine\u2010related working memory difficulties underpinned by reduced frontoparietal responses"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5124-7041","authenticated-orcid":false,"given":"Robert J.","family":"Roy","sequence":"first","affiliation":[{"name":"Department of Psychology University of Nebraska\u2010Lincoln  Lincoln Nebraska USA"},{"name":"Center for Brain, Biology, and Behavior  Lincoln Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad A.","family":"Parvaz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Ichan School of Medicine at Mount Sinai  New York New York USA"},{"name":"Department of Neuroscience Ichan School of Medicine at Mount Sinai  New York New York USA"},{"name":"Department of Artificial Intelligence and Human Health Ichan School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7518-572X","authenticated-orcid":false,"given":"Ken T.","family":"Wakabayashi","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Nebraska\u2010Lincoln  Lincoln Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J. R.","family":"Blair","sequence":"additional","affiliation":[{"name":"Child and Adolescent Mental Health Centre, Mental Health Services  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8209-4295","authenticated-orcid":false,"given":"Nicholas A.","family":"Hubbard","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Nebraska\u2010Lincoln  Lincoln Nebraska USA"},{"name":"Center for Brain, Biology, and Behavior  Lincoln Nebraska 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