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This study aimed to identify active ingredients, evaluate therapeutic efficacy in an MA addiction rat model and delineate pharmacodynamic mechanisms using metabolomics. In vitro phytochemical profiling characterized 258 drug\u2010related compounds, with 87 prototype entities mainly identified in rat plasma. NBDC significantly attenuated METH\u2010induced behavioural anomalies and modulated neurotransmitter levels, notably increasing brain DA and serotonin (5\u2010HT) content with concomitant upregulation of D1 dopamine receptor (DRD1) and 5\u2010HT1A receptor (5\u2010HT1AR) expression, ameliorating hippocampal pathology. Metabolomic analysis identified histamine receptor as a potential target and revealed the involvement of NBDC in metabolic pathways associated with cocaine addiction, amphetamine abuse and Parkinson's disease. Conclusively, NBDC presents a promising therapeutic agent for mitigating MA addiction through a synergistic interplay of multiple constituents, pharmacological targets and metabolic pathways.<\/jats:p>","DOI":"10.1111\/adb.70005","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T13:03:46Z","timestamp":1731330226000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integration of pharmacochemistry, pharmacodynamics and metabolomics to reveal active ingredients and mechanism of Nan Bao detox capsule alleviating methamphetamine addiction"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4579-1075","authenticated-orcid":false,"given":"Bin","family":"Zhang","sequence":"first","affiliation":[{"name":"Hunan Academy of Chinese Medicine  Changsha China"},{"name":"Hunan University of Chinese Medicine  Changsha 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