{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:43:10Z","timestamp":1787013790194,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R21AA020594"],"award-info":[{"award-number":["R21AA020594"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Background. Alcohol use disorder (AUD) is prevalent during young adulthood, and this risk may be linked to aberrations in neurodevelopmental processes. Prior studies examining white matter (WM) integrity in young adult individuals with AUD have shown considerable variability. This is due in part because traditional tensor related metrics such as fractional anisotropy are subject to limitations in estimation precision at sites of crossing or curving fibres. In response, to better understand differences in WM integrity of young adults with AUD, this study sought to uniquely employ two WM integrity measurement domains. Methods. Twenty\u2010five participants (\n                    <jats:italic>n\u2009=<\/jats:italic>\n                    \u200914 female) diagnosed with AUD and 33 social drinkers (\n                    <jats:italic>n\u2009=<\/jats:italic>\n                    \u200919 female) underwent structural and diffusion\u2010weighted imaging. Diffusion\u2010weighted images were processed to extract diffusion tensor (DTI) and neurite orientation dispersion and density (NODDI) metrics in major WM tracts for comparison between the two groups. Results. We identified decreased axial diffusivity in portions of frontolimbic and corticostriatal WM tracts, and increased orientation dispersion at overlapping tracts in participants with AUD relative to social drinkers. Conclusions. These results may represent early\u2010stage neural immune system activation and axonal reorganization targeting frontolimbic and corticostriatal WM tracts, therein associated with behaviours linked to AUD. This is the first study combining DTI and NODDI metrics to identify early\u2010stage indicators of alcohol\u2010related neurobiological pathology in young adults with AUD compared to social drinkers.\n                  <\/jats:p>","DOI":"10.1111\/adb.70019","type":"journal-article","created":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T05:00:19Z","timestamp":1742619619000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["White Matter Differences in Early\u2010Stage Alcohol Use Disorder: Diffusion Tensor and Neurite Orientation Dispersion and Density Measures of Structural Integrity"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7975-0554","authenticated-orcid":false,"given":"Sunderland\u00a0K.","family":"Baker","sequence":"first","affiliation":[{"name":"Department of Biobehavioral Health The Pennsylvania State University  University Park Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1800-0813","authenticated-orcid":false,"given":"Eric\u00a0D.","family":"Claus","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Health The Pennsylvania State University  University Park Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2215\u20100366(16)00104\u20108"},{"issue":"1","key":"e_1_2_11_3_1","first-page":"14","article-title":"Vital Signs: Binge Drinking Prevalence, Frequency, and Intensity Among Adults \u2010 United States, 2010","volume":"61","author":"Centers for Disease Control and Prevention","year":"2012","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"e_1_2_11_4_1","volume-title":"Alcohol Use Disorder (AUD) in the United States: Age Groups and Demographic Characteristics","year":"2024"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14048"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12767"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dr.2007.08.003"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2015.06.003"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/1067828x.2011.555272"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cogdev.2017.03.002"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcab154"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2019.01.007"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010005\u20102267\u20106"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300623"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.09.022"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.10.039"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2018.09.004"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00092"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530\u20100277.2007.00603.x.f"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.03.072"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167884"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2021.616132"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010023\u201006380\u20100"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12493"},{"key":"e_1_2_11_25_1","volume-title":"User's Guide for the SCID\u2010CV Structured Clinical Interview for DSM\u2010IV Disorders: Clinical Version","author":"First M. 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