{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:35:46Z","timestamp":1792593346082,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004214","name":"Pamukkale \u00dcniversitesi","doi-asserted-by":"publisher","award":["2022HZDP025"],"award-info":[{"award-number":["2022HZDP025"]}],"id":[{"id":"10.13039\/501100004214","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004214","name":"Pamukkale \u00dcniversitesi","doi-asserted-by":"publisher","award":["2022HZDP026"],"award-info":[{"award-number":["2022HZDP026"]}],"id":[{"id":"10.13039\/501100004214","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Opioid use disorder (OUD) is a chronic, relapsing brain disorder. The efficacy of brain stimulation methods in the treatment of OUD has been increasingly investigated. However, the efficacy of deep transcranial magnetic stimulation, namely, wide\u2010volume TMS, in the treatment of OUD has not been investigated. The aim of this randomized, double\u2010blind, sham\u2010controlled add\u2010on study was to evaluate the efficacy of wide\u2010volume TMS using a double\u2010cone coil in participants with OUD. A total of 55 OUD patients were recruited and randomized to receive either active or sham TMS. Active wide\u2010volume TMS treatment was applied to the left dorsolateral prefrontal cortex (DLPFC) in the active TMS group using a double\u2010cone coil, twice daily for 2\u2009weeks, at a frequency of 10 Hz. Sham TMS was also applied to the same region in the placebo group using a placebo coil. Opioid Craving Visual Analogue Scale (OC\u2010VAS), Hamilton Depression Rating Scale (HDRS), Hamilton Anxiety Rating Scale (HARS) and Barratt Impulsiveness Scale\u201011 (BIS\u201011) were measured before treatment, at the end of treatment, and 2\u2009months after treatment. A total of 21 patients from the active TMS group and 19 patients from the sham TMS group completed the study. Although the active TMS group exhibited more reduction in craving and a less pronounced increase in buprenorphine\u2010naloxone dose during the treatment period compared to the sham group, these differences did not reach statistical significance. This study suggests that while wide\u2010volume TMS using a double\u2010cone coil applied to the left DLPFC was well tolerated, it did not produce statistically significant improvements in craving, depression, anxiety, or impulsivity when compared to the sham treatment. However, the observed trends warrant further investigation with larger sample sizes and refined protocols.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:bold>Trial Registration:<\/jats:bold> This trial was registered at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link> (NCT06081985)<\/jats:title><\/jats:sec>","DOI":"10.1111\/adb.70057","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T16:19:46Z","timestamp":1750349986000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Deep Transcranial Magnetic Stimulation in Patients With Opioid Use Disorder: A Double\u2010Blind, Placebo\u2010Controlled Randomized Trial"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2233-3657","authenticated-orcid":false,"given":"Soner","family":"Guldas","sequence":"first","affiliation":[{"name":"Department of Psychiatry Gaziantep State Hospital  Gaziantep Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0474-4467","authenticated-orcid":false,"given":"Selim","family":"Tumkaya","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Psychiatry Pamukkale University  Denizli Turkey"},{"name":"Faculty of Medicine, Department of Neuroscience Pamukkale University  Denizli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4721-7288","authenticated-orcid":false,"given":"Bengu","family":"Yucens","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Psychiatry Pamukkale University  Denizli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,19]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"2013"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-018-1058-y"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0137-5"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1151\/spp021113"},{"key":"e_1_2_12_6_1","first-page":"16","volume-title":"Opioid Kullan\u0131m Bozuklu\u011funda Tan\u0131 ve Tedavi K\u0131lavuzu","author":"Evren C.","year":"2017"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S414782"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.02.006"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.13121"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajad.12638"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2017.01.412"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00952990.2020.1849247"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(16)00104-8"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2019.04.020"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2012.02.005"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2017.03.008"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2014.925583"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X17666190409142555"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/10550490590949488"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2019.19070720"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2022.110513"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.01147"},{"key":"e_1_2_12_23_1","volume-title":"Research Randomizer","author":"Urbaniak G. 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