{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:14:33Z","timestamp":1788455673369,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009438","name":"National Center of Neurology and Psychiatry","doi-asserted-by":"publisher","award":["4\u20101"],"award-info":[{"award-number":["4\u20101"]}],"id":[{"id":"10.13039\/501100009438","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K15749"],"award-info":[{"award-number":["22K15749"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21H05173"],"award-info":[{"award-number":["JP21H05173"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23H04979"],"award-info":[{"award-number":["23H04979"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004330","name":"Smoking Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Craving is an intense, strong urge to engage in addictive behaviours. Craving is supposed to be modulated by the connectivity between the amygdala and the ventral striatum (VS), a pivotal pathway for reward\u2010seeking behaviours. However, whether and how this connectivity underlies craving for gambling remains unclear, limiting our understanding of the pathophysiology of gambling disorder (GD). To address this issue, we analysed resting\u2010state functional connectivity (rs\u2010FC) between the amygdala and VS in 51 GD patients and 45 healthy participants. Craving for gambling was assessed using the Gambling Craving Scale (GACS). Among three GACS subscales, Desire exhibited a significant correlation with rs\u2010FC in the right amygdala\u2013VS, while Anticipation and Relief showed no significant associations. Causal mediation analysis revealed that depressive symptoms significantly mediated the relationship between rs\u2010FC in the right amygdala\u2013VS and Desire. These findings suggest that the amygdala\u2013VS connectivity elicits the intense desire for gambling through negative emotions.<\/jats:p>","DOI":"10.1111\/adb.70065","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T07:44:37Z","timestamp":1752738277000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Amygdala\u2013Ventral Striatum Functional Connectivity Underlies Craving in Gambling Disorder: A Mediating Role of Depressive Symptoms"],"prefix":"10.1111","volume":"30","author":[{"given":"Yuzuki","family":"Ishikawa","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Katsuragi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiko","family":"Inagaki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kota","family":"Ebina","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiteru","family":"Mutsuda","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morio","family":"Aki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mami","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaka","family":"Hamamoto","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Ando","sequence":"additional","affiliation":[{"name":"Ando Clinic  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihisa","family":"Iriki","sequence":"additional","affiliation":[{"name":"Osaka Psychiatric Medical Center  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Miyagi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Mizuta","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariyoshi","family":"Takemura","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuro","family":"Murao","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Graduate School of Medicine Kyoto University  Kyoto Japan"},{"name":"Department of Psychiatry and Behavioral Sciences Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosaku","family":"Kawada","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Oishi","sequence":"additional","affiliation":[{"name":"Human Brain Research Center, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiko","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Institute of Science Tokyo  Tokyo Japan"},{"name":"Medical Institute of Developmental Disabilities Research Showa University  Tokyo Japan"},{"name":"Center for Brain Integration Research Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiya","family":"Murai","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5051-6978","authenticated-orcid":false,"given":"Kosuke","family":"Tsurumi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425787"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0015043"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/09652140050111717"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010\u2010440X(91)90066\u2010L"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360\u20100443.1991.tb01732.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.2011.06298.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1556\/2006.2022.00080"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0376\u20108716(93)90042\u2010O"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2014.01.010"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10899\u2010015\u20109587\u20101"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2020.106533"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10899\u2010019\u201009887\u20104"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005053\u2010200207000\u201000007"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306\u20104522(82)90067\u20107"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3533"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1581\u201004.2004"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.89766"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2013.00213"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10194"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.12.038"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074353"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.85"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2006.11.014"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360\u20100443.2002.00015.x"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.06.032"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1124\/pharmrev.120.000083"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02107111"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.paid.2005.05.008"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1556\/2006.7.2018.38"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2018.11.038"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010023\u201004811\u20104"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.12669"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2021.643272"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2004.05.006"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890423349"},{"key":"e_1_2_12_38_1","volume-title":"Beck Depression Inventory\u2013II","author":"Beck A. T.","year":"1996"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360\u20100443.1991.tb01879.x"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360\u20100443.1993.tb02093.x"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896\u20106273(02)00569\u2010X"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.04.127"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647\u2010200109000\u201000002"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.06.033"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1007779107"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1301245110"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881109106907"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881119855972"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2016.06.003"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.70011"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1080\/14459795.2020.1713852"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.70065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T06:48:57Z","timestamp":1753426137000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adb.70065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/adb.70065"],"URL":"https:\/\/doi.org\/10.1111\/adb.70065","archive":["Portico"],"relation":{},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70065"}}