{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T19:22:32Z","timestamp":1781896952001,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016506","name":"Alcohol and Drug Abuse Institute, University of Washington","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016506","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["CX\u2010001787"],"award-info":[{"award-number":["CX\u2010001787"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Cue\u2010induced craving\u2014the desire to use a drug triggered by exposure to cues associated with prior use\u2014is a central mechanism in the development and maintenance of problematic substance use behaviours. Drug cues have the power to induce craving even in long\u2010term abstinent individuals, which has led clinicians to advise patients to avoid the people, places and objects that are associated with their use. This preliminary study builds on prior behavioural research that demonstrates that exposure to multimodal drug cues can increase craving even after the drug cues are removed from the environment.<\/jats:p><jats:p>We used a novel fMRI paradigm that combined multimodal cannabis cue\u2010exposure with resting\u2010state functional connectivity to examine positive and negative functional connectivity (i.e., correlations and anticorrelations) between the ventral tegmental area (VTA) and the striatum, a circuit critically involved in reward processing and addiction. Intrinsic VTA\u2010striatal connectivity was measured in 28 individuals who use cannabis regularly (CU group) and 26 age\u2010 and sex\u2010matched controls who had never used cannabis before and after multimodal (visual and olfactory) cannabis cue exposure. Craving was assessed at baseline using the Marijuana Craving Questionnaire\u2010Short Form to test whether VTA\u2010striatal connectivity was correlated with self\u2010reported craving measured prior to the fMRI scan. There were no significant group differences in VTA\u2010striatal connectivity during the baseline resting\u2010state scan. However, following cue exposure, CU participants showed significantly greater VTA\u2010caudate connectivity compared to controls. Further, within the CU group, baseline craving was positively correlated with VTA\u2010striatal connectivity at both time points.<\/jats:p><jats:p>Our preliminary findings support prior investigations demonstrating that alterations of mesostriatal connectivity are associated with cannabis use and craving in individuals with problematic cannabis use. In addition, the observation of altered connectivity during the post\u2010cue resting\u2010state scan\u2014after multimodal cannabis cues were removed\u2014suggests a potential neural mechanism by which cue exposure may contribute to relapse vulnerability in individuals with problematic cannabis use.<\/jats:p>","DOI":"10.1111\/adb.70067","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T03:54:56Z","timestamp":1754625296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Increased Mesostriatal Intrinsic Connectivity Associated With Cue Exposure in Adult Cannabis Users: Preliminary Findings"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4417-4224","authenticated-orcid":false,"given":"Natalia\u00a0M.","family":"Kleinhans","sequence":"first","affiliation":[{"name":"Department of Radiology University of Washington  Seattle WA USA"},{"name":"Integrated Brain Imaging Center University of Washington  Seattle WA USA"},{"name":"Institute on Human Development and Disability University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7449-2832","authenticated-orcid":false,"given":"Garth\u00a0E.","family":"Terry","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Washington  Seattle WA USA"},{"name":"Department of Psychiatry and Behavioral Sciences University of Washington  Seattle WA USA"},{"name":"Mental Illness Research, Education, and Clinical Center VA Puget Sound Health Care System  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dahyeon","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9923-8259","authenticated-orcid":false,"given":"Sarah\u00a0F.","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Washington  Seattle WA USA"},{"name":"Integrated Brain Imaging Center University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary\u00a0E.","family":"Larimer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of Washington  Seattle WA USA"},{"name":"Department of Psychology University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(93)90013-P"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2008.0093"},{"issue":"2","key":"e_1_2_13_4_1","first-page":"151","article-title":"Relapse Prevention. An Overview of Marlatt's Cognitive\u2010Behavioral Model","volume":"23","author":"Larimer M. E.","year":"1999","journal-title":"Alcohol Research & Health"},{"key":"e_1_2_13_5_1","first-page":"1","article-title":"Relapse Prevention for Alcohol and Drug Problems","volume":"2","author":"Marlatt G. A.","year":"2005","journal-title":"Relapse prevention: Maintenance Strategies in the Treatment of Addictive Behaviors"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2006.00320.x"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1037\/adb0000779"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.2001.961014196.x"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2019.04.006"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.97.s01.2.x"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2007.12.010"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2008.12.010"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-021-00649-4"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07590.x"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-021-05973-x"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903863106"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.046"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2014.04.002"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2013.06.005"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2016.07.004"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0017705"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.5127\/jep.027412"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2018.09.015"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2024.09.006"},{"issue":"10","key":"e_1_2_13_25_1","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.1764","article-title":"FMRI Activation to Cannabis Odor Cues Is Altered in Individuals at Risk for a Cannabis Use Disorder","volume":"10","author":"Kleinhans N. M.","year":"2020","journal-title":"Brain and Behavior: A Cognitive Neuroscience Perspective"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-021-05938-0"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2017.11.004"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2023.03.045"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2007.02114.x"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2010.02.017"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1993.tb02093.x"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2011.2131152"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.06.047"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0931"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.044"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2058-08.2008"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5221-08.2009"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1544-06.2006"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2008.09.004"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5306.1593"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/10673220490910844"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2011.00417.x"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2009.09.015"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-006-0578-x"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.08.048"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2016.165"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0190-17.2017"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06976"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2024.120604"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.099"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2015.09.008"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.70067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T15:18:10Z","timestamp":1760023090000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adb.70067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":50,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/adb.70067"],"URL":"https:\/\/doi.org\/10.1111\/adb.70067","archive":["Portico"],"relation":{},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"2024-12-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70067"}}