{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T10:43:52Z","timestamp":1767869032901,"version":"3.49.0"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"publisher","award":["TSGH\u2010E\u2010114283"],"award-info":[{"award-number":["TSGH\u2010E\u2010114283"]}],"id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"publisher","award":["TSGH\u2010D\u2010112119"],"award-info":[{"award-number":["TSGH\u2010D\u2010112119"]}],"id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"publisher","award":["TSGH\u2010E113288"],"award-info":[{"award-number":["TSGH\u2010E113288"]}],"id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Brain\u2010derived neurotrophic factor (BDNF) and personality traits play a crucial role in the development of alcohol use disorder (AUD). However, the relationship between the <jats:italic>BDNF<\/jats:italic> gene, personality and AUD remains unclear. This study aimed to explore the role of BDNF gene variants, personality traits and impulsivity in both the presence of AUD and the age of onset of alcohol dependence. We also examined the interaction between BDNF gene variants and personality traits among individuals with AUD. Eleven polymorphisms encompassing the whole BDNF gene region were genotyped. The Tridimensional Personality Questionnaire (TPQ) and the Barratt Impulsiveness Scale\u201011 (BIS\u201011) assessed personality traits and impulsivity. Pearson's Chi\u2010square, HAPLOVIEW software, logistic regression, independent <jats:italic>t<\/jats:italic> tests and linear regression were conducted to investigate the associations between BDNF variants, personality traits and impulsivity in patients with AUD. Five\u2010hundred eighty\u2010five AUD patients and 546 normal controls (NC) were recruited for the study. Although no polymorphisms were significantly associated with AUD after Bonferroni correction in gender\u2010 or age\u2010stratified analyses, one specific haplotype block (TCA haplotype of rs1519480\/rs6265\/rs11030101) was related to AUD <jats:styled-content>(<jats:italic>p<\/jats:italic>\u2009=\u20096.16\u2009\u00d7\u200910<\/jats:styled-content><jats:sup><jats:styled-content>\u22125<\/jats:styled-content><\/jats:sup><jats:styled-content>)<\/jats:styled-content>. TPQ and BIS\u201011 results revealed that AUD patients, particularly those with early\u2010onset AUD (EOAUD), exhibited significantly higher scores in Novelty Seeking (NS) and Harm Avoidance (HA) compared to NC. Additionally, the <jats:italic>BDNF<\/jats:italic> SNP rs6484320 was significantly associated with higher BIS\u201011 scores in the AUD group. High HA, NS, impulsivity, and the BDNF gene's specific haplotype may influence AUD's development. The findings may provide new insights into the genetic and psychological factors contributing to AUD.<\/jats:p>","DOI":"10.1111\/adb.70074","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T13:59:06Z","timestamp":1754488746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["BDNF Haplotype and Personality Traits May Influence the Development of Alcohol Use Disorder in the Han Chinese Population"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2683-5717","authenticated-orcid":false,"given":"Yi\u2010Hsin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of General Medicine, Tri\u2010Service General Hospital National Defense Medical Center  Taipei Taiwan (ROC)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Wei","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tri\u2010Service General Hospital National Defense Medical Center  Taipei Taiwan (ROC)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Long","family":"Lin","sequence":"additional","affiliation":[{"name":"Graduate Institute of Medical Sciences National Defense Medical Center  Taipei Taiwan (ROC)"},{"name":"Department of Psychiatry, Hsinchu Branch Taoyuan Armed Forces General Hospital  Hsinchu Taiwan (ROC)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin\u2010Chang","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tri\u2010Service General Hospital National Defense Medical Center  Taipei Taiwan (ROC)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8330-9569","authenticated-orcid":false,"given":"Chun\u2010Yen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tri\u2010Service General Hospital National Defense Medical Center  Taipei Taiwan (ROC)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Chieh","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tri\u2010Service General Hospital National Defense Medical Center  Taipei Taiwan (ROC)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ta\u2010Chuan","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tri\u2010Service General Hospital National Defense Medical Center  Taipei Taiwan (ROC)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Yun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tri\u2010Service General Hospital National Defense Medical Center  Taipei Taiwan (ROC)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo\u2010Hsing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Biology National Defense Medical Center  Taipei Taiwan (ROC)"},{"name":"Brain Research Center National Defense Medical Center  Taipei Taiwan (ROC)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4143-2491","authenticated-orcid":false,"given":"San\u2010Yuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tri\u2010Service General Hospital National Defense Medical Center  Taipei Taiwan (ROC)"},{"name":"Graduate Institute of Medical Sciences National Defense Medical Center  Taipei Taiwan (ROC)"},{"name":"Brain Research Center National Defense Medical Center  Taipei Taiwan (ROC)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"World Health Organization \u201cGlobal Status Report on Alcohol and Health 2018 \u201dhttps:\/\/www.who.int\/publications\/i\/item\/9789241565639."},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0086-08.2008"},{"key":"e_1_2_12_4_1","first-page":"1","article-title":"Allostatic View of Motivation: Implications for Psychopathology","volume":"50","author":"Koob G. 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