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We showed previously that withdrawal from chronic ethanol exposure (CIE\/WD) produced population\u2010 and sex\u2010specific alterations to distinct glutamatergic inputs. The current study examined GABAergic function in these distinct populations (BLA<jats:sup>NAC<\/jats:sup> and BLA<jats:sup>BNST<\/jats:sup> neurons). We found that CIE\/WD diminished feed\u2010forward GABA release from lateral paracapsular cells (LPCs) specifically onto male BLA<jats:sup>NAC<\/jats:sup> neurons. Pharmacological manipulations showed this dysregulation was caused by the enhanced activity of \u03bc\u2010opioid receptors. CIE\/WD did not alter evoked GABA release from local interneurons onto either population. However, females expressed greater GABA release from these local interneurons compared to males. Immunostaining and confocal microscopy revealed lower colocalization between the GABA vesicular transporter, vGAT and parvalbumin in females, indicating that greater GABA releases from local interneurons in this sex may be a compensatory response to lower levels of perisomatic innervation by PV<jats:sup>+<\/jats:sup> interneurons. Consistent with this, there were no sex differences related to spontaneous GABAergic synaptic events although CIE\/WD decreased their frequency specifically in BLA<jats:sup>BNST<\/jats:sup> neurons from both sexes. Altogether, these findings demonstrate that CIE\/WD dynamically alters GABAergic function in an input\u2010, sex\u2010 and population\u2010specific fashion. Moreover, there are basal sex differences in both the anatomy of BLA GABAergic synapses and their function.<\/jats:p>","DOI":"10.1111\/adb.70080","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T05:55:37Z","timestamp":1758520537000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chronic Intermittent Ethanol and Withdrawal Suppress Evoked and Spontaneous GABA Release Onto Distinct Populations of Basolateral Amygdala Principal Neurons"],"prefix":"10.1111","volume":"30","author":[{"given":"Michaela\u00a0E.","family":"Price","sequence":"first","affiliation":[{"name":"Department of Translational Neuroscience Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailey\u00a0X.","family":"Egido\u2010Betancourt","sequence":"additional","affiliation":[{"name":"Department of Translational 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