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This process relies on neurocircuitry involved in emotional and behavioural regulation, particularly the ventromedial PFC (vmPFC) and orbitofrontal cortex (OFC), along with limbic and ventral striatal regions (e.g., amygdala, hippocampus and nucleus accumbens). These systems are highly sensitive to the neurotoxic effects of alcohol, which may disrupt their ability to flexibly adapt in response to acute stress. This study investigated state\u2010dependent changes (termed \u2018flexibility\u2019) in vmPFC\u2010limbic\/striatal and OFC\u2010limbic\/striatal functional connectivity from rest to acute stress in individuals with AUD versus matched controls and examined associations with coping strategies. Twenty\u2010four adults with AUD (<jats:italic>age<\/jats:italic><jats:sub><jats:italic>mean<\/jats:italic><\/jats:sub>\u2009=\u200933, 11F) and 23 matched controls (<jats:italic>age<\/jats:italic><jats:sub><jats:italic>mean<\/jats:italic><\/jats:sub>\u2009=\u200932, 11F) underwent fMRI during resting\u2010state followed by the Montreal Imaging Stress Task (MIST) and completed the COPE Inventory. Functional connectivity between vmPFC\u2010limbic\/striatal and OFC\u2010limbic\/striatal regions was assessed during rest and stress (MIST) conditions. Group differences in state\u2010dependent changes in functional connectivity were analysed using repeated\u2010measures ANCOVA. Functional connectivity between the right OFC\u2013right amygdala and right OFC\u2013right hippocampus increased from resting\u2010state to the MIST in the control group, but this shift was not present in the AUD group (group x condition, <jats:italic>p<\/jats:italic><jats:sub><jats:italic>FDR<\/jats:italic><\/jats:sub> &lt;\u20090.05). Although connectivity did not differ between groups during the MIST (<jats:italic>p<\/jats:italic>'s\u2009&gt;\u20090.2), the AUD group exhibited elevated connectivity between these regions at rest (<jats:italic>p<\/jats:italic>'s\u2009&lt;\u20090.05). Moreover, among controls, increased right OFC\u2013right hippocampus connectivity from rest to MIST was associated with more adaptive versus maladaptive coping (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Compared to controls, individuals with AUD exhibited a pattern of inflexible OFC\u2010amygdala and OFC\u2010hippocampus functional connectivity under changing stress conditions. Diminished stress\u2010related connectivity changes in AUD appeared to be driven by elevated functional connectivity at rest. Future studies should test whether this resting\u2010state connectivity pattern reflects an allostatic state that constrains the system's capacity to flexibly respond to acute stress.<\/jats:p>","DOI":"10.1111\/adb.70083","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T06:44:41Z","timestamp":1755499481000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Inflexible Orbitofrontal Cortex Functional Connectivity From Rest to Acute Stress in Alcohol Use Disorder"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9935-9635","authenticated-orcid":false,"given":"Dylan\u00a0E.","family":"Kirsch","sequence":"first","affiliation":[{"name":"Department of Psychology University of California, Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany\u00a0C.","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Psychology University of California, Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate\u00a0M.","family":"Wassum","sequence":"additional","affiliation":[{"name":"Department of Psychology University of California, Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5734-9444","authenticated-orcid":false,"given":"Lara\u00a0A.","family":"Ray","sequence":"additional","affiliation":[{"name":"Department of Psychology University of California, Los Angeles  Los Angeles California USA"},{"name":"Department of Psychiatry and Biobehavioral Sciences University of California, Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5528-4918","authenticated-orcid":false,"given":"Erica\u00a0N.","family":"Grodin","sequence":"additional","affiliation":[{"name":"Department of Psychology University of California, Los Angeles  Los Angeles California USA"},{"name":"Department of Psychiatry and Biobehavioral Sciences University of California, Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/2470547017698140"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2236-1"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.09.008"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-007-0050-6"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.01.037"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.1991.52.26"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/08897079909511409"},{"key":"e_1_2_11_9_1","volume-title":"Relapse Prevention: Maintenance Strategies in the Treatment of Addictive Behaviors","author":"Marlatt G. 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