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This study investigated the therapeutic potential of full agonism or positive allosteric modulation of the serotonin 2C receptor (5\u2010HT\n                    <jats:sub>2C<\/jats:sub>\n                    R) in addressing alcohol binge drinking and seeking behaviours in mice. Using a drinking\u2010in\u2010the\u2010dark paradigm and a context\u2010induced reinstatement model following punishment\u2010imposed abstinence, we assessed the acute effects of 5\u2010HT\n                    <jats:sub>2C<\/jats:sub>\n                    R ligands lorcaserin, CYD\u20101\u201079, VA012 and CTW0415 on alcohol intake and seeking behaviours in mice. Results showed that while lorcaserin effectively reduced both alcohol consumption and seeking behaviours, the 5\u2010HT\n                    <jats:sub>2C<\/jats:sub>\n                    R positive allosteric modulators (PAMs) did not significantly alter these behaviours over the range of doses examined. These findings suggest that 5\u2010HT\n                    <jats:sub>2C<\/jats:sub>\n                    R PAMs, at the tested doses, may lack intrinsic efficacy in modulating alcohol use. However, our lorcaserin data demonstrate that targeting 5\u2010HT\n                    <jats:sub>2C<\/jats:sub>\n                    R remains a valid approach to reduce behaviours associated with AUD.\n                  <\/jats:p>","DOI":"10.1111\/adb.70099","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T01:26:43Z","timestamp":1762824403000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Effect of Serotonin 5\u2010HT\n                    <sub>2C<\/sub>\n                    Receptor Modulation on Binge Drinking and Alcohol\u2010Seeking in Female Mice"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1510-880X","authenticated-orcid":false,"given":"Roberta\u00a0G.","family":"Anversa","sequence":"first","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre The University of Melbourne  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Toxicology University of Texas Medical Branch  Galveston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn\u00a0A.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Center for Addiction Sciences and Therapeutics, and Department of Pharmacology and Toxicology University of Texas Medical Branch  Galveston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6836-727X","authenticated-orcid":false,"given":"Andrew\u00a0J.","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre The University of Melbourne  Parkville VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4722-6897","authenticated-orcid":false,"given":"Erin\u00a0J.","family":"Campbell","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Pharmacy, 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