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Cooper Medical Research Foundation","doi-asserted-by":"publisher","award":["F20221117"],"award-info":[{"award-number":["F20221117"]}],"id":[{"id":"10.13039\/501100001061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cannabis use disorder (CUD) affects ~22\u2010million people globally and is characterised by difficulties in cutting down and quitting use, but the underlying neurobiology remains unclear. We examined resting\u2010state functional connectivity (rsFC) between regions of interest (ROIs) of the addiction neurocircuitry and the rest of the brain in 65 individuals with moderate\u2010to\u2010severe CUD who reported attempts to cut down or quit, compared to 42 controls, and explored the association between rsFC and cannabis exposure and related problems, to elucidate potential drivers of rsFC alterations. The CUD group showed greater rsFC than controls between ROIs implicated in reward processing and habitual substance use (i.e., nucleus accumbens, putamen and pallidum) and occipito\/parietal areas implicated in salience processing and disinhibition. Putamen\u2010occipital rsFC correlated with levels of problematic cannabis use and depression symptoms. CUD appears to show neuroadaptations of the addiction neurocircuitry, previously demonstrated in other substance use disorders.<\/jats:p>","DOI":"10.1111\/adb.70105","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T04:30:22Z","timestamp":1764822622000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Addiction Neurocircuitry and Resting\u2010State Functional Connectivity in Cannabis Use Disorder: An fMRI Study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7220-1624","authenticated-orcid":false,"given":"Hannah","family":"Thomson","sequence":"first","affiliation":[{"name":"Neuroscience of Addiction and Mental Health Program, Healthy Brain and Mind Research Centre, School of Behavioural and Health Sciences, Faculty of Health Sciences Australian Catholic University  Fitzroy Victoria 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