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However, the role of CB1R in the cerebellum, despite that structure's exceptionally high CB1R density, remains unexplored. We therefore tested the hypothesis that cerebellar CB1R contributes to regulating impulsive behaviour, alcohol consumption and seeking. Male Wistar rats, adolescent (PND25), adult (PND90) and aged (PND365), were assessed on the delay discounting task (DDT) and for voluntary alcohol intake\u2010conditioned place preference (ACPP). CB1R levels were quantified via immunofluorescence in the CRUS II and interposed nucleus. Separate cohorts were used for voluntary alcohol consumption and alcohol\u2010conditioned place preference (ACPP). Results showed that adolescent rats displayed significantly greater impulsivity and alcohol consumption than adults and aged rats, and only adolescents developed ACPP. CB1R expression peaked in adolescents across both cerebellar regions, but only Crus II levels correlated positively with impulsivity (\n                    <jats:italic>k<\/jats:italic>\n                    value), indicating a region\u2010 and age\u2010specific contribution. These data reveal, for the first time, that CB1R in cerebellar Crus II selectively underpins adolescent impulsive choice and alcohol consumption and seeking, highlighting both a novel brain locus and a critical developmental window for endocannabinoid modulation.\n                  <\/jats:p>","DOI":"10.1111\/adb.70107","type":"journal-article","created":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T05:39:59Z","timestamp":1764481199000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Age\u2010Dependent Differences in Cerebellar CB1 Receptor Expression and Its Association With Impulsivity and Alcohol Intake in Rats"],"prefix":"10.1111","volume":"30","author":[{"given":"Johana\u00a0P.","family":"G\u00f3mez\u2010Villatoro","sequence":"first","affiliation":[{"name":"Laboratorio de Ontogenia y Adicciones, Departamento de Fisiolog\u00eda, Facultad de Medicina Universidad Nacional Aut\u00f3noma de M\u00e9xico  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalitza\u00a0A.","family":"Alvarado\u2010Ramirez","sequence":"additional","affiliation":[{"name":"Laboratorio de Ontogenia y Adicciones, Departamento de Fisiolog\u00eda, Facultad de Medicina Universidad Nacional Aut\u00f3noma de M\u00e9xico  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavio","family":"Amancio\u2010Belmont","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Neurociencias, Instituto de Fisiolog\u00eda Celular Universidad Nacional Aut\u00f3noma de M\u00e9xico  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0949-3070","authenticated-orcid":false,"given":"M\u00f3nica","family":"M\u00e9ndez\u2010D\u00edaz","sequence":"additional","affiliation":[{"name":"Laboratorio de Ontogenia y Adicciones, Departamento de Fisiolog\u00eda, Facultad de Medicina Universidad Nacional 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