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These conditioned responses can be attenuated through extinction learning, a core component of cue exposure therapy (CET). CET is effective in some individuals with AUD but not all, so it is necessary to develop strategies to identify and intervene with individuals unlikely to benefit from CET. Another method for attenuating conditioned responding is retrieval\u2010extinction, which renders the original associative memory labile via distinct neural mechanisms. We recently demonstrated that CO\n                    <jats:sub>2<\/jats:sub>\n                    reactivity predicts extinction memory for both fear and food cues, and fear memory after retrieval\u2010extinction, and CO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010induced orexin\/c\u2010Fos colocalization predicts fear extinction memory. The purpose of the current study was to examine whether the predictive power of CO\n                    <jats:sub>2<\/jats:sub>\n                    reactivity might extend to alcohol\u2010seeking behaviour after extinction or retrieval\u2010extinction in male and female rats. We also examined the relationship between CO\n                    <jats:sub>2<\/jats:sub>\n                    reactivity, return of alcohol\u2010seeking behaviour and CO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010induced orexin\/c\u2010Fos colocalization. Male and female rats first underwent alcohol drinking induction in the homecage followed by dependence via exposure to chronic intermittent ethanol vapour or control air and homecage drinking. All rats then underwent Pavlovian alcohol conditioning followed by either standard extinction or retrieval\u2010extinction. They then received a long\u2010term memory (LTM) test and CO\n                    <jats:sub>2<\/jats:sub>\n                    challenge followed by euthanasia for brain harvesting. CO\n                    <jats:sub>2<\/jats:sub>\n                    reactivity differentially predicted LTM after extinction and retrieval\u2010extinction. There were no relationships between orexin\/c\u2010Fos colocalization and CO\n                    <jats:sub>2<\/jats:sub>\n                    reactivity or LTM. The predictive power of CO\n                    <jats:sub>2<\/jats:sub>\n                    reactivity extends to alcohol\u2010seeking behaviour after extinction and retrieval\u2010extinction in alcohol dependent and nondependent male and female rats, while its relationship with orexin\/c\u2010Fos colocalization does not. CO\n                    <jats:sub>2<\/jats:sub>\n                    reactivity could be used as a screening tool to determine whether an individual may be a good candidate for CET or a retrieval\u2010extinction\u2013based approach.\n                  <\/jats:p>","DOI":"10.1111\/adb.70116","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T09:08:02Z","timestamp":1769072882000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["CO\n                    <sub>2<\/sub>\n                    Reactivity but Not CO\n                    <sub>2<\/sub>\n                    \u2010Induced Orexin\/c\u2010Fos Colocalization Differentially Predicts Alcohol\u2010Seeking Behaviour After Extinction and Retrieval\u2010Extinction in Rats"],"prefix":"10.1111","volume":"31","author":[{"given":"Marissa","family":"Raskin","sequence":"first","affiliation":[{"name":"Interdisciplinary Neuroscience Program 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