{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T23:54:37Z","timestamp":1779926077749,"version":"3.53.1"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Alcohol use disorder (AUD) is a chronic, relapsing condition that causes extensive systemic damage, yet clinically actionable biomarkers remain lacking. Exosome\u2010derived microRNAs (exo\u2010miRNAs) have emerged as highly stable extracellular indicators of disease state and active regulators of alcohol\u2010induced pathological processes. Unlike proteins or lipids, miRNAs are selectively packaged, cell\u2010type specific and mechanistically linked to inflammation, hepatocellular injury, synaptic dysfunction and neuroimmune signalling. Here, we provide an integrated and updated review of how chronic alcohol exposure reshapes exo\u2010miRNA cargo across organs\u2014particularly the liver, immune system and central nervous system. We summarize the biogenesis and selective sorting of exo\u2010miRNAs, highlight key candidate miRNAs such as miR\u2010122, miR\u2010155, miR\u2010192, miR\u201029a, miR\u201030a and miR\u2010124 and analyse their representative gene targets and downstream effects. Furthermore, we distinguish exo\u2010miRNAs with diagnostic potential from those representing promising therapeutic targets and discuss major limitations, including specificity relative to other drugs of abuse. By integrating mechanistic and translational evidence, this review aims to clarify the biological and clinical value of exo\u2010miRNAs and to provide guidance for future precision\u2010medicine strategies in AUD.<\/jats:p>","DOI":"10.1111\/adb.70124","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:00:43Z","timestamp":1769598043000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Research Progress of Exosome\u2010Derived microRNA in Alcohol Use Disorders: A Critical Review"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3838-4025","authenticated-orcid":false,"given":"Bo","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Psychology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting\u00a0ting","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Psychology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Ma","sequence":"additional","affiliation":[{"name":"Karamay Hospital of Integrated Chinese and Western Medicine  Karamay Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u00a0ping","family":"Jiang","sequence":"additional","affiliation":[{"name":"Reproductive and Genetic Department of Tai'an Central Hospital Affiliated to Qingdao University  Tai'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u00a0mei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000093099"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000065436.24221.63"},{"key":"e_1_2_12_4_1","volume-title":"Global Status Report on Alcohol and Health and Treatment of Substance Use Disorders","author":"World Health Organization","year":"2024"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2015.05.031"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201011916\u20100"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agx024"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddaa038"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12903"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/15622975.2020.1834618"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(11)70286\u20101"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2018.03.023"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010019\u20100537\u20109"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.5980303"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04367"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1017576108"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2011.06.009"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2014.00085"},{"key":"e_1_2_12_19_1","first-page":"665","article-title":"Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles","volume":"15","author":"Colombo M.","year":"2014","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1596"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804549105"},{"key":"e_1_2_12_22_1","first-page":"1","article-title":"Elucidation of Exosome Migration Across the Blood\u2013Brain Barrier Model","volume":"235","author":"Chen C. C.","year":"2016","journal-title":"Journal of Controlled Release"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.309795"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2014.130"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.07.002"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3978"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1465324921004655"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2014.05.005"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13020222"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.53671"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.20517\/evcna.2025.47"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.787356"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology8020025"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2018.03.009"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0201144"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep09991"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010019\u20101529\u2010x"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.12.023"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.2960"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010015\u20100623\u20109"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25873"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14131025"},{"key":"e_1_2_12_43_1","unstructured":"Knockout of microRNA\u201021 Attenuates Alcoholic Hepatitis Through the VHL\/NF\u2010\u03baB Signaling Pathway in Hepatic Stellate Cells."},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102016\u2010311861"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI141513"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.01.035"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110294"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2017.04.010"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S464249"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12079\u2010017\u20100421\u20107"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.259324"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700673R"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00573"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.70124","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/adb.70124","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.70124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:13:08Z","timestamp":1773011588000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adb.70124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,28]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/adb.70124"],"URL":"https:\/\/doi.org\/10.1111\/adb.70124","archive":["Portico"],"relation":{},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,28]]},"assertion":[{"value":"2025-10-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70124"}}