{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:51:05Z","timestamp":1777949465036,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The present study aimed to investigate the expression of OIP5\u2010AS1 in alcohol use disorder and to explore its potential clinical relevance. A total of 78 patients with alcohol use disorder and 36 healthy controls were enrolled in this study. Clinical data were collected for all participants. The expression levels of OIP5\u2010AS1 were quantified using quantitative real\u2010time polymerase chain reaction (RT\u2010PCR). Receiver operating characteristic (ROC) analysis was subsequently performed to evaluate the diagnostic value of OIP5\u2010AS1. StarBase\u2010based bioinformatics analysis suggested that OIP5\u2010AS1 may function within a miRNA\u2010mediated regulatory network influencing SERPINA3 expression. OIP5\u2010AS1 expression levels, as determined by RT\u2010PCR, were markedly higher in patients with alcohol use disorder than in healthy controls (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Patients were stratified into high\u2010 and low\u2010expression groups based on the median OIP5\u2010AS1 level. Comparative analyses of baseline characteristics and clinical parameters showed that body mass index (BMI) was significantly lower in the high\u2010expression group, and this inverse association between OIP5\u2010AS1 expression and BMI remained statistically significant in subsequent logistic regression analyses. ROC analysis demonstrated that OIP5\u2010AS1 had strong diagnostic performance, yielding an area under the curve of 0.9091 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001), with a sensitivity of 100% and a specificity of 75% at the defined cutoff. In conclusion, OIP5\u2010AS1 expression was significantly increased in patients with alcohol use disorder and was inversely associated with BMI. In addition, OIP5\u2010AS1 demonstrated good diagnostic performance in distinguishing patients with alcohol use disorder from healthy controls. These findings suggest that OIP5\u2010AS1 may have potential clinical relevance in alcohol use disorder and merit further investigation.\n                  <\/jats:p>","DOI":"10.1111\/adb.70146","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T02:30:39Z","timestamp":1774492239000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Expression and Clinical Significance of the Long Non\u2010Coding RNA OIP5\u2010AS1 in Alcohol Use Disorder"],"prefix":"10.1111","volume":"31","author":[{"given":"Meng\u00a0ya","family":"Zhu","sequence":"first","affiliation":[{"name":"Huai'an No. 3 People's Hospital Huaian Second Clinical College of Xuzhou Medical University  Huaian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Huai'an No. 3 People's Hospital Huaian Second Clinical College of Xuzhou Medical University  Huaian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u00a0Jia","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Psychology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3838-4025","authenticated-orcid":false,"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Psychology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong 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