{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T02:02:00Z","timestamp":1784685720181,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Long\u2010acting naltrexone is a first\u2010line pharmacotherapy for alcohol use disorder (AUD), but clinical response is heterogeneous and the underlying biology remains incompletely understood. In a randomised, double\u2010blind, placebo\u2010controlled trial of naltrexone implants (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200970), the prespecified primary endpoint\u2014percentage of heavy\u2010drinking days (PHDD) over 24\u2009weeks\u2014favoured naltrexone (median 1.49% vs. 13.39%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.042). In a prespecified Week\u201012 mechanistic lipidomics substudy, untargeted liquid chromatography\u2013mass spectrometry (LC\u2013MS) profiling was performed in a responder\u2010enriched subset comprising naltrexone responders (RN,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200918), placebo\u2010treated participants (PL,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910) and age\u2010 and BMI\u2010matched healthy male controls (HC,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910). We derived membrane\u2010related indices reflecting two prespecified axes of phospholipid remodelling: headgroup balance (PC\/PE) and acyl\u2010chain composition (arachidonic acid [AA] and n\u20103 polyunsaturated fatty acids within phospholipid pools). RN showed higher PC\/PE and coordinated acyl\u2010chain shifts versus PL, with species\u2010level changes preferentially moving toward the healthy\u2010control direction. Exploratory analyses in naltrexone nonresponders (NR,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910) revealed partial Lands\u2010cycle\u2010related shifts but lacked the broader dual\u2010axis configuration observed in RN. In RN\u2009+\u2009PL (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200928), higher n\u20103 in PE and lower AA in PE at Week 12 were prospectively associated with greater subsequent heavy\u2010drinking burden. These findings support a dual\u2010axis membrane remodelling phenotype associated with naltrexone response and prospectively linked to heavy\u2010drinking burden in AUD, providing a biologically grounded framework for future mechanistic and biomarker studies.\n                  <\/jats:p>","DOI":"10.1111\/adb.70165","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:29:46Z","timestamp":1778635786000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Membrane\u2010Centric Plasma Lipidomic Signature of Response to Long\u2010Acting Naltrexone in Alcohol Use Disorder"],"prefix":"10.1111","volume":"31","author":[{"given":"Liyao","family":"Huang","sequence":"first","affiliation":[{"name":"The School of Clinical Medicine Hunan University of Chinese Medicine  Changsha Hunan China"},{"name":"Department of Addiction Medicine Hunan Institute of Mental Health, The Second People's Hospital of Hunan Province (Brain Hospital of Hunan Province)  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Fuzhou Neuropsychiatric Hospital Affiliated to Fujian Medical University  Fuzhou Fujian China"},{"name":"The Second General Hospital of Fuzhou Neuropsychiatric Prevention and Treatment Hospital  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinling","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Addiction Medicine Hunan Institute of Mental Health, The Second People's Hospital of Hunan Province (Brain Hospital of Hunan Province)  Changsha Hunan China"},{"name":"College of Integrated Chinese and Western Medicine Hunan University of Chinese Medicine  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0006-4300","authenticated-orcid":false,"given":"Jubo","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Addiction Medicine Hunan Institute of Mental Health, The Second People's Hospital of Hunan Province (Brain Hospital of Hunan Province)  Changsha Hunan China"},{"name":"College of Integrated Chinese and Western Medicine Hunan University of Chinese Medicine  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiwen","family":"Tian","sequence":"additional","affiliation":[{"name":"The School of Clinical Medicine Hunan University of Chinese Medicine  Changsha Hunan China"},{"name":"Department of Addiction Medicine Hunan Institute of Mental Health, The Second People's Hospital of Hunan Province (Brain Hospital of Hunan Province)  Changsha Hunan 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