{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T01:02:25Z","timestamp":1784595745721,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471519"],"award-info":[{"award-number":["82471519"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Underage drinking has become a global public health concern. One of the major causes of underage drinking is stress. The orexin system has been reported to be involved in both alcohol addiction and stress. However, few studies have examined this system, especially among adolescents. Therefore, we constructed protein\u2013protein interaction (PPI) networks to confirm that orexin receptors are connected to stress\u2010 and alcohol dependence\u2010related genes, providing a theoretical basis for our experimental approach. Animal experiments employed the conditioned place preference (CPP), the foot\u2010shock stress model and the enzyme\u2010linked immunosorbent assay (ELISA), to elucidate the role of the orexin system in the stress\u2010induced alcohol addiction\u2010related behaviour among adolescent mice. Our results revealed that there were interactions among orexin system, chronic\/acute stress and alcohol dependence related proteins. Otherwise, chronic stress can increase the animals' vulnerability to alcohol addition\u2010related behaviour. Additionally, acute foot\u2010shock can promote alcohol\u2010seeking behaviour reinstatement and facilitate orexin concentrations in brain regions that have been shown to be associated with reward and addiction. Moreover, the inhibition of orexin receptors can attenuate the formation and reinstatement of alcohol addiction\u2010like behaviour among adolescent mice. Collectively, our findings indicate that orexin system may be a pivotal target for preventing stress\u2010induced alcohol addiction and reinstatement among the adolescents.<\/jats:p>","DOI":"10.1111\/adb.70173","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:57:03Z","timestamp":1782262623000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Orexin System Modulates Stress\u2010Induced Alcohol Preference and Reinstatement in Adolescents: Bioinformatics and Experimental Evidence"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2408-0761","authenticated-orcid":false,"given":"Wenhao","family":"He","sequence":"first","affiliation":[{"name":"Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders The Second Xiangya Hospital of Central South University  Changsha Hunan 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