{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T01:02:25Z","timestamp":1784595745710,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PID\u20102021\u2010127256OB\u2010I00"],"award-info":[{"award-number":["PID\u20102021\u2010127256OB\u2010I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD24\/0003\/0010"],"award-info":[{"award-number":["RD24\/0003\/0010"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Alcohol use disorder (AUD) is linked to cognitive deficits that can persist even after prolonged abstinence. Research highlighted associations between plasma apolipoproteins and cognition in AUD. This study examines the longitudinal evolution of plasma apolipoproteins and inflammation in AUD patients during early and prolonged abstinence and their association with cognitive recovery. Thirty\u2010three AUD patients from an outpatient hospital alcoholism programme were evaluated at baseline (\n                    <jats:italic>t<\/jats:italic>\n                    \u2009=\u20090), 6\u2009months (\n                    <jats:italic>t<\/jats:italic>\n                    \u2009=\u20091) and 12\u2009months (\n                    <jats:italic>t<\/jats:italic>\n                    \u2009=\u20092), along with 34 healthy controls. Cognitive performance was assessed using the TEDCA test, which measures general cognitive function (GCF). Biological assessments included plasma pro\u2010inflammatory biomarkers (LPS and LBP) and several apolipoproteins (APOAI, APOAII, APOB, APOCII, APOE, APOJ and APOM). AUD patients showed elevated plasma LPS, APOAI, APOE, APOJ and downregulated APOM, which all normalized at\n                    <jats:italic>t<\/jats:italic>\n                    \u2009=\u20091, whereas cognitive improvement was significant at t\u2009=\u20092 compared to controls. Mixed\u2010effects models including all covariates and within\u2010between person decomposition, followed by correlation matrix and reduced mixed models sensitivity analysis support robust associations between better GCF and (1) the duration of abstinence and (2) within\u2010person reductions in LPS, although apolipoprotein changes should be considered exploratory at this level. Prolonged abstinence in AUD patients normalizes plasma peripheral inflammation and apolipoprotein levels and improves cognition. Although APOAI and APOM showed opposite trajectories, as opposite biomarkers in AUD diagnosis reported previously, only the duration of abstinence and normalization of within\u2010person blood LPS levels over time emerged as predictors of cognitive recovery.\n                  <\/jats:p>","DOI":"10.1111\/adb.70174","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:08:17Z","timestamp":1782958097000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal Cognitive Evolution in Alcohol Use Disorder Patients: Role of Inflammation, Time of Abstinence and Apolipoprotein Profile"],"prefix":"10.1111","volume":"31","author":[{"given":"Berta","family":"Escudero","sequence":"first","affiliation":[{"name":"Department of Psychobiology and Behavioral Science Methods, Faculty of Psychology Complutense University of Madrid  Pozuelo de Alarc\u00f3n Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital Universitario 12 de Octubre (imas12)  Madrid Spain"},{"name":"Research Network in Primary Care in Addictions (RIAPAd)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Olmos","sequence":"additional","affiliation":[{"name":"Department of Social Psychology and Methodology, Faculty of Psychology Aut\u00f3noma University of Madrid  C\/Iv\u00e1n Pavlov Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Arias","sequence":"additional","affiliation":[{"name":"Department of Psychobiology and Behavioral Science Methods, Faculty of Psychology Complutense University of Madrid  Pozuelo de Alarc\u00f3n Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital Universitario 12 de Octubre (imas12)  Madrid Spain"},{"name":"Research Network in Primary Care in Addictions (RIAPAd)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9614-4062","authenticated-orcid":false,"given":"Laura","family":"Orio","sequence":"additional","affiliation":[{"name":"Department of Psychobiology and Behavioral Science Methods, Faculty of Psychology Complutense University of Madrid  Pozuelo de Alarc\u00f3n Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital Universitario 12 de Octubre (imas12)  Madrid Spain"},{"name":"Research Network in Primary Care in Addictions (RIAPAd)  Madrid 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