{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:22:19Z","timestamp":1787530939260,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The underlying neurobiological mechanisms of chronic alcohol consumption, particularly neuroinflammation and immune system dysregulation, have been extensively studied in recent years. In this process, the identification of objective biomarkers that can predict treatment response and enable personalized medicine approaches is of critical importance. This study aimed to evaluate the potential predictive value of tenascin\u2010C (TNC), an extracellular matrix protein, neopterin, a marker of cellular immune activation and pro\u2010inflammatory cytokines interferon\u2010gamma (IFN\u2010\u03b3), tumour necrosis factor\u2010alpha (TNF\u2010\u03b1) and interleukin\u20106 (IL\u20106), during the treatment process for alcohol use disorder (AUD). This prospective observational cohort study included 30 patients admitted to an AUD treatment centre and 31 healthy controls. Serum TNC, IL\u20106, TNF\u2010\u03b1 and IFN\u2010\u03b3 levels were measured using the ELISA method. Clinical outcomes were assessed using the SCL\u201090\u2010R and API\u2010K scales. Serum samples were collected from patients at admission and on the 7th day of detoxification treatment. Baseline serum TNC levels in the alcohol group (131.78\u2009\u00b1\u200950.92\u2009ng\/mL) were significantly higher than in the healthy control group (63.92\u2009\u00b1\u200923.85\u2009ng\/mL). In the alcohol group, TNC (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.007) and AST (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.025) levels decreased significantly, while vitamin B12 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002) and platelet count (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.012) increased. No significant difference was observed in neopterin and cytokine levels (TNF\u2010\u03b1, IL\u20106 and IFN\u2010\u03b3) between baseline and follow\u2010up measurements. Clinical assessments showed significant improvements in depression (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.041), anxiety (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.014) and total symptom scores (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.026) on the SCL\u201090\u2010R scale. ROC analysis showed that a reduction of 28.22% or more in TNC predicted clinical improvement with an overall accuracy rate of 73.33%.\n                  <\/jats:p>","DOI":"10.1111\/adb.70181","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:12:49Z","timestamp":1784873569000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Predictive Value of Tenascin\u2010C, Neopterin and Pro\u2010Inflammatory Cytokines (IFN\u2010\u03b3, TNF\u2010\u03b1, IL\u20106) in Alcohol Use Disorder Treatment Response"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8559-5098","authenticated-orcid":false,"given":"Guleser","family":"Akpinar","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Basaksehir Cam and Sakura City Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulsen","family":"Sener","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Basaksehir Cam and Sakura City Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0051-0281","authenticated-orcid":false,"given":"Enes Faruk","family":"Altunkili\u00e7","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Mental Health and Disorders Bakirkoy Prof. Dr. Mazhar Osman Mental Health and Neurological Diseases Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emre","family":"Yazgec","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Mental Health and Disorders Bakirkoy Prof. Dr. Mazhar Osman Mental Health and Neurological Diseases Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0584-5131","authenticated-orcid":false,"given":"Alp Batuhan","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Faculty of Medicine Biruni University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuri Mehmet","family":"Basan","sequence":"additional","affiliation":[{"name":"Department of Neurology Istanbul Basaksehir Cam and Sakura City Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huseyin Aycan","family":"Ozsemerci","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Basaksehir Cam and Sakura City Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13113938"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-025-02630-3"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9082668"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2023.106083"},{"issue":"1","key":"e_1_2_11_6_1","first-page":"112","article-title":"Alcohol Use Disorder Is Differently Associated With Psychotic Symptoms According to Underlying Psychiatric Disorders: A General Population Study","volume":"55","author":"Pignon B.","year":"2020","journal-title":"Psychological 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S.","year":"2003","journal-title":"Alcohol Research & Health"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2020.02.166"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.70181","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/adb.70181","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/adb.70181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:18:01Z","timestamp":1787530681000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/adb.70181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,23]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/adb.70181"],"URL":"https:\/\/doi.org\/10.1111\/adb.70181","archive":["Portico"],"relation":{},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,23]]},"assertion":[{"value":"2026-01-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70181"}}