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The present study investigated whether pharmacological manipulation of corticosteroid signalling within the dorsal striatum influences morphine\u2010induced conditioned place preference (CPP) and dopamine transporter (DAT) regulation. Male Wistar rats were implanted with bilateral intra\u2010dorsal striatal cannulae and subjected to the CPP paradigm. Before conditioning sessions, animals received bilateral intra\u2010dorsal striatal infusions of corticosterone, the glucocorticoid receptor (GR) antagonist RU\u201038486 or the mineralocorticoid receptor (MR) antagonist spironolactone. Behavioural preference, locomotor activity and DAT immunoreactivity were subsequently assessed. Morphine reliably induced CPP and reduced DAT immunoreactivity in the dorsal striatum. Corticosterone, RU\u201038486 and spironolactone each significantly attenuated morphine\u2010induced CPP and prevented the reduction in DAT immunoreactivity without altering locomotor activity. The convergence of these pharmacologically distinct manipulations on similar behavioural and DAT outcomes suggests that perturbation of corticosteroid\u2010sensitive signalling within the dorsal striatum modulates opioid reward and associated dopaminergic plasticity. Importantly, the present findings do not establish whether corticosterone's effect is mediated by classical GR signalling, rapid corticosteroid actions or GR\u2010independent mechanisms. Given the role of the dorsal striatum in addiction\u2010related learning and the transition towards habitual and compulsive drug seeking, these findings identify corticosteroid\u2013dopamine interactions within this region as an important mechanism for further investigation in opioid use disorders.<\/jats:p>","DOI":"10.1111\/adb.70185","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T03:45:18Z","timestamp":1789357518000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Corticosteroid Receptor Modulation in the Dorsal Striatum Prevents Morphine\u2010Induced Place Preference and Reduction in Dopamine Transporter (DAT) Immunoreactivity in Rats"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2262-735X","authenticated-orcid":false,"given":"Payman","family":"Raise\u2010Abdullahi","sequence":"first","affiliation":[{"name":"Research Center of 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