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White\u2010matter fibres are a necessary component of those circuits. However, the extent to which mesocorticolimbic white\u2010matter tracts are altered in methamphetamine addiction is unknown. The current study addressed this gap as well as sought to determine relationships with neurofunctional and behavioural deficits concerning nondrug rewards. Multimodal MRI was acquired from 92 people with problematic methamphetamine\u2010use experience (MA\n                    <jats:sup>+<\/jats:sup>\n                    ) and 98 methamphetamine\u2010na\u00efve controls (MA\n                    <jats:sup>\u2212<\/jats:sup>\n                    ). Diffusion tractography mapped probabilistic fibre paths connecting midbrain presynaptic dopamine hubs to striatal and medial orbitofrontal areas highly sensitive to rewards. MA\n                    <jats:sup>+<\/jats:sup>\n                    exhibited microstructural alterations (via fractional anisotropy [FA]) along this mesocorticolimbic tract\u2014in particular, white\u2010matter segments running through anterior limb of the internal capsule (ALIC\n                    <jats:sub>FA<\/jats:sub>\n                    : MA\n                    <jats:sup>+<\/jats:sup>\n                    \u2009&gt;\u2009MA\n                    <jats:sup>\u2212<\/jats:sup>\n                    ) and near the medial orbitofrontal target area (mOFC\n                    <jats:sub>FA<\/jats:sub>\n                    : MA\n                    <jats:sup>+<\/jats:sup>\n                    \u2009&lt;\u2009MA\n                    <jats:sup>\u2212<\/jats:sup>\n                    ). In addition, task\u2010fMRI revealed that MA\n                    <jats:sup>+<\/jats:sup>\n                    exhibited reduced activations to monetary rewards within the striatal and mOFC area versus MA\n                    <jats:sup>\u2212<\/jats:sup>\n                    . Moreover, MA\n                    <jats:sup>+<\/jats:sup>\n                    participants reported they attributed lower hedonic value and lesser motivational salience to broader nondrug rewards\/pleasant experiences relative to MA\n                    <jats:sup>\u2212<\/jats:sup>\n                    . Further, within MA\n                    <jats:sup>+<\/jats:sup>\n                    participants, those exhibiting decreased ALIC\n                    <jats:sub>FA<\/jats:sub>\n                    or mOFC\n                    <jats:sub>FA<\/jats:sub>\n                    reported attributing lower hedonic value to nondrug rewards\/experiences relative to their peers\u2014with a similar correlation found for ALIC\n                    <jats:sub>FA<\/jats:sub>\n                    and motivational\u2010salience reports. Our findings identified microstructural alterations in a mesocorticolimbic white\u2010matter tract plausibly supporting reward\u2010related dopaminergic signalling in people experienced with methamphetamine. Such alterations may play a role in the lower valuation of nondrug rewards and diminished motivation to pursue typical\/nondrug activities associated with methamphetamine use.\n                  <\/jats:p>","DOI":"10.1111\/adb.70186","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:25:12Z","timestamp":1789626312000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mesocorticolimbic Dopamine\u2010Reward Tract Alterations and the \u2018Dark Side\u2019 of Methamphetamine Addiction"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5124-7041","authenticated-orcid":false,"given":"Robert J.","family":"Roy","sequence":"first","affiliation":[{"name":"Department of Psychology University of Nebraska\u2013Lincoln  Lincoln Nebraska USA"},{"name":"Center for Brain, Biology, and Behavior  Lincoln Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken T.","family":"Wakabayashi","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Nebraska\u2013Lincoln  Lincoln Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J. R.","family":"Blair","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8209-4295","authenticated-orcid":false,"given":"Nicholas A.","family":"Hubbard","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Nebraska\u2013Lincoln  Lincoln Nebraska USA"},{"name":"Center for Brain, Biology, and Behavior  Lincoln Nebraska 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