{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T08:37:28Z","timestamp":1777192648789,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T00:00:00Z","timestamp":1360540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aimed to (i) describe methadone dosing before, during and after pregnancy, (ii) to compare the incidence of neonatal abstinence syndrome (<jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content>) between those with dose decreases and those with steady or increasing doses and (iii) to describe prescribed medication use among opioid\u2010dependent pregnant women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Two<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>rish tertiary care maternity hospitals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>A total of 117 pregnant women on methadone maintenance treatment (<jats:styled-content style=\"fixed-case\">MMT<\/jats:styled-content>) recruited between<jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>uly 2009 and<jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>uly 2010.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Electronic dispensing records from addiction clinics and the<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>rimary<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>are<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>eimbursement<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ervice were used to determine methadone doses and dispensed medications in the year preceding and the month following delivery. The<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>innegan score was used to determine need for medical treatment of<jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>Of the 117 participants, sufficient dosing data were available for 89 women treated with<jats:styled-content style=\"fixed-case\">MMT<\/jats:styled-content>throughout pregnancy; 36 (40.4%) had their dose decreased from a mean pre\u2010pregnancy dose of 73.3\u2009mg [standard deviation (SD) 25.5] to a third\u2010trimester dose of 58.0\u2009mg (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>26.0). The corresponding figures for those with increased doses (<jats:italic>n<\/jats:italic>\u2009=\u200931, 34.8%) were 70.7\u2009mg (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>25.3) and 89.7\u2009mg (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>21.0), respectively. The incidence of medically treated<jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content>did not differ between dosage groups. Antidepressants were dispensed for 29 women (25.7%) during pregnancy, with the rate decreasing from pre\u2010pregnancy to postpartum. Benzodiazepines were prescribed for 43 women (38.0%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>rish health service, opioid\u2010dependent women frequently have their methadone dose decreased during pregnancy but this does not appear to affect the incidence of the neonatal abstinence syndrome in their babies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/add.12078","type":"journal-article","created":{"date-parts":[[2012,12,10]],"date-time":"2012-12-10T10:23:46Z","timestamp":1355135026000},"page":"762-770","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Methadone dosing and prescribed medication use in a prospective cohort of opioid\u2010dependent pregnant women"],"prefix":"10.1111","volume":"108","author":[{"given":"Brian J.","family":"Cleary","sequence":"first","affiliation":[{"name":"Coombe Women and Infants University Hospital Dublin 8 Ireland"},{"name":"School of Pharmacy Royal College of Surgeons in Ireland Dublin 2 Ireland"},{"name":"Department of Obstetrics and Gynaecology School of Medicine Trinity College Dublin 2 Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kieran","family":"Reynolds","sequence":"additional","affiliation":[{"name":"School of Pharmacy Royal College of Surgeons in Ireland Dublin 2 Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maeve","family":"Eogan","sequence":"additional","affiliation":[{"name":"The Rotunda Hospital Dublin 1 Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P.","family":"O'Connell","sequence":"additional","affiliation":[{"name":"Coombe Women and Infants University Hospital Dublin 8 Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Fahey","sequence":"additional","affiliation":[{"name":"HRB Centre for Primary Care Research Division of Population Health Sciences Royal College of Surgeons in Ireland Dublin 2 Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"Gallagher","sequence":"additional","affiliation":[{"name":"School of Pharmacy Royal College of Surgeons in Ireland Dublin 2 Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Clarke","sequence":"additional","affiliation":[{"name":"The Rotunda Hospital Dublin 1 Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin J.","family":"White","sequence":"additional","affiliation":[{"name":"Coombe Women and Infants University Hospital Dublin 8 Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"McDermott","sequence":"additional","affiliation":[{"name":"The Rotunda Hospital Dublin 1 Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"O'Sullivan","sequence":"additional","affiliation":[{"name":"Coombe Women and Infants University Hospital Dublin 8 Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deirdre","family":"Carmody","sequence":"additional","affiliation":[{"name":"Addiction Services Health Service Executive Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Gleeson","sequence":"additional","affiliation":[{"name":"Addiction Services Health Service Executive Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deirdre J.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Coombe Women and Infants University Hospital Dublin 8 Ireland"},{"name":"Department of Obstetrics and Gynaecology School of Medicine Trinity College Dublin 2 Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002209.pub2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/10550490802266276"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/11632820-000000000-00000"},{"key":"e_1_2_6_5_1","first-page":"141","article-title":"Neonatal abstinence syndrome: assessment and management","volume":"2","author":"Finnegan L. 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